Best Nootropic Supplements (2021) Review Top Brain Boosters

Find the best nootropic supplements in 2021 and review top natural brain boosting cognitive enhancement formulas without negative side effects and real benefits

Chicago, IL, April 23, 2021 (GLOBE NEWSWIRE) -- Everyone from a Fortune 500 CEO to freshmen in college relies on a new category of supplement known as nootropics to enhance their cognitive ability. Sometimes referred to as “smart drugs”, nootropics are designed to enhance your ability to learn, focus, remember, think critically.

Nootropics are even being endorsed by the likes of Joe Rogan, Tim Ferriss, and other celebrities.

Although new, there’s plenty of evidence that nootropics can enhance cognition but you need to be careful before buying a nootropic. Thankfully, our research team examined many of the most popular nootropics and determined the best products to boost cognition for 2021 and beyond.

Ranking the Best Nootropic Supplements in 2021

Strangely enough, the modern nootropic supplement industry can be traced directly back to the film Limitless. If you haven’t seen the movie, we’ll give you a quick rundown. The protagonist stumbles upon a crazy pill that allows him to become an incredible genius overnight. He runs the stock market, secures a beautiful girlfriend, and lives his dream life. Most of us are average intelligence, so it makes sense why the narrative of the film resonated with so many people around the world. The idea of being able to take a single pill and instantly become an Einstein-level genius is a tough dream to pass up.

Is there a real-life Limitless pill? This is a question we get a lot, and it’s also a question that many similar supplement review websites regularly answer. The concept behind the movie involves someone becoming an unprecedented genius after just one pill. Who wouldn’t dream of something so beautifully simple? The unfortunate truth is that most people will never see any version of the Limitless pill. The reason why: the pill does not exist. No supplement will turn you into Albert Einstein, and no pill can help you win the girl of your dreams and dominate the stock market.

But the nootropic industry has been around for longer than this blockbuster film. Scientists have worked for centuries on ways to help improve human memory, cognitive function, and general intelligence. Some pills focus primarily on memory, while others are more comprehensive in their potential benefits and applications. Some nootropics improve brain capacity so well that they might actually be able to provide users with improved reflexes and attention spans. These benefits have been observed in multiple research studies, which we will take a closer look at later in the review.

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Because the Limitless movie took nootropics into the mainstream, the past decade has been filled with supplements claiming benefits that they cannot possibly provide for average users. The first result of this mainstream transition has been an oversaturation of the market. Nootropics used to be a niche cottage industry in the larger supplement market, but the infamy of this film helped to take the market to the masses. While this oversaturation has led to the creation of quite a few great formulas from reputable nootropic-producing companies, it has also led to a not-so-great effect: scams.

The nootropic industry’s worst scam offenders often prey upon the basic human instinct to want to become smarter. As humans, we evolved to prize intelligence and memory above all else. In fact, it’s how we survived the Ice Age and avoided species extinction. We do not want our readers to get scammed by ineffective nootropic supplements. Avoiding scams is easier than it sounds. We did the groundwork to help consumers get the most efficient and scientifically backed formulas on the current nootropic market.

Read on to learn more about our picks for the top nootropic supplements of 2021. We carefully vetted all of the formulas on our list for scientific support, ingredient quality, and company transparency.

#1 – Mind Lab Pro

Mind Lab Pro is an advanced nootropic stack that combines 11 science backed nootropic compounds to create the ultimate brain supplement. What’s even better is that many of these individual ingredients are able to synergistically work together to amplify the effects of Mind Lab Pro.

By taking Mind Lab Pro, you can boost your energy, increase your production of neurotransmitters like GABA, serotonin, and acetylcholine, and protect your brain from oxidative stress. This results in a significant improvement in memory, critical thinking, learning, and focus.

Plus, Mind Lab Pro is manufactured in an GMP-certified Lab in the United States and it comes with a standard 30-day money back guarantee so you’ve got plenty of time to evaluate its’ effectiveness.

Overall, Mind Lab Pro is one of the few complete nootropic supplements and should be on the top of your list if you’re searching for a nootropic.

#2 – Nezena Neuro Focus

Neuro Focus is a potent nootropic manufactured by the well-respected company Nezena. It contains several of our favorite nootropic compounds like niacin, glutamic acid, DMAE, L-theanine, and magnesium.

All of these ingredients have some form of clinical research backing up their brain boosting claims, which Is why Nezena holds up well compared to other popular nootropics.

As the name would imply, Neuro Focus’ main benefit is improved focus. Therefore, you are best suited to choose Neuro Focus if you’re someone who have troubling focusing but many not have problems with critical thinking or memory.

Nuzena is also one of the most affordable nootropics available too, so it may be a good option if you’re on a budget or want the most bang for your buck.

#3 – Sane Vitaae

Sane Vitaae Anti-Aging & Brain Health Formula is unique in that it’s less of a traditional nootropic and more of an anti-aging product. It relies on five main ingredients that it claims can reverse the effects of aging on the brain.

These five ingredients are Vitamin D, Folate, a proprietary blend called VitaalMind™, citicoline, and coenzyme Q-10. There is some evidence that Q-10 and citicoline can reduce oxidative stress on the brain, so it appears these claims have some truth to them.

Since it is designed more as an anti-aging supplement, Sane Vitaae is probably best suited for older adults suffering from brain fog, mood swings, or memory loss. If you’re younger, say college aged or a little older, you may find another product to be more effective for you.

#4 – NaturalCell NeuroActiv6

NaturalCell NeuroActiv6 is a nootropic drink designed specifically to low oxidative stress, reduce cortisol levels, and raise BDNF levels in your brain. It contains natural herbal supplements like ashwagandha, turmeric, grape seed extract, citicoline, and coffee fruit extract to improve cognition.

The main mechanism behind Natural Cell is through BNDF production. BNDF stands for “brain-derived neurotrophic factor” and it is a protein critical for the growth of neurons. It also helps to repair damaged cells.

Natural Cell increase BNDF production, which increases the rate at which your body can rejuvenate damaged and weaker neurons. Repairing these neurons helps them communicate faster and more efficiently, which is why Natural Cell is an excellent supplement for improving critical thinking, focus, & memory.

#5 – ProMind Complex

ProMind Complex uses a natural complex of vitamins and minerals like bacopa, St. John’s Wort, huperzine a, ginkgo, and vinpocetine – all of which are staples in the nootropic industry. The only downside is we couldn’t find the exact formula, which is a problem.

Despite that, we could discover that ProMind is manufactured in a GMP-certified facility here in the United States and comes with a full 60-day money back guarantee, both of which are good signs.

Although we can’t find the exact formula, ProMind contains several of the most well studied and proven brain boosting ingredients. It’s formula is designed to enhance virtually every function of your brain and for that reason, ProMind is a solid choice.

#6 – SynapseXT

SynapseXT is a unique nootropic designed to strengthen neural connections in the brain and to eliminate tinnitus. Tinnitus is the feeling of ringing in the ears and studies have found tinnitus can cause long term brain damage by weakening certain networks in the brain.

The active ingredients in SynapseXT include green tea, hibiscus, vitamin c, hawthorn berry, and vitamin B. All of these ingredients are powerful anti-inflammatory compounds and vitamin B may help strengthen neurotransmitter connections in the brain.

SynapseXT is far from your normal nootropic and really designed for people with tinnitus and to repair neural networks. Otherwise, if you don’t have tinnitus, it may not be dosed strong enough to really boost your cognition and may not be a great choice.

#7 – Noobru™

Noobru™ is an exciting new nootropic drink that describes itself as “fuel for peak performance.” It comes packed with brain boosting ingredients like, KSM-66 ashwagandha, choline, huperzine A, and Vitamin B6, many of which are backed by dozens of clinical studies.

Customers seem to rave about Noobru and its’ ability to boost cognitive performance but many cannot get over the price. A one month’s supply will cost you around $128, which is almost double most of the nootropics we reviewed. Still Noobru is an excellent nootropic drink and it’s easy to mix formula is great if you want something on the road.

#8 – Brain Pill

It’s not often you see a company pay to have their product clinically studied before coming to market but that’s exactly what Leading Edge Health did with their nootropic product Brain Pill.

In their 67-day study, Brain Pill significantly improved learning, memory, concentration, and critical thinking. Their all natural formula contains proven winners like ginkgo biloba, Cognizin, DHA, vinepocetine, bacopa monnieri, and plenty of other cognitive enhancers.

Truthfully, the fact Brain Pill is clinically studied should mean we have it higher on our list. When you combine that with a 67-day money back guarantee and a doctor recommendation, it’s no wonder Brain Pill is quickly becoming one of the most popular nootropics.

#9 – Nootrogen

Nootrogen contains ingredients like bacopa monnieri, glutamine, HCL, green tea, and DMAE extract to enhance cognitive function and to reduce inflammation in the brain. As an added bonus, it also contains glutamic acid, which works as a neurotransmitter in the brain.

Studies have shown DMAE supports acetylcholine levels in the brain, an essential neurotransmitter for memory. L-tyrosine also act as a precursor to dopamine, which may help support mood and reduce stress.

Overall, Nootrogen is a well formulated product with plenty of proven ingredients. Available for as little as $19.99/bottle, Nootrogen delivers results and provides you with excellent value since it won’t break your piggy bank.

#10 – Organixx Ageless Brain

Organixx Ageless Brain is brain rejuvenation supplement designed to repair and restore neural connections in the brain to enhance critical thinking, memory recall, and focus.

Inside Ageless Brain is a large number of anti-inflammatory ingredients like camu camu, bacopa monnieri, cacao extract, and cinnamon. Organixx claims these ingredients reduce the brain inflammation and oxidative stress that weakens your brain’s ability to make connections between neurons.

The science behind neural connections is very complicated and it’s hard to say whether any of these specific ingredients directly affects neurons in the brain. However, bacopa, camu camu, and a few other ingredients are known to enhance cognition and that alone makes Ageless Brain worth trying.

#11 – Vitality Now Youthful Brain

Vitality Now Youthful Brain is a nootropic specifically targeted towards older adults looking to rejuvenate and restore their cognitive abilities. Endorsed by Dr. Sam Walters, a world-renowned memory expert, Youthful Brain describes as the ultimate supplement to eliminate “senior moments” and to boost memory, concentration, and focus.

Youthful Brain’s all-natural formula includes vitamin B12, bacopa, huperzine A, and phosphatidylserine – many of which are backed by dozens of studies.

Based on Youthful Brain’s formula, it’s clear that this product is best suited for seniors struggling with memory recall and concentration. Otherwise, you may want to focus on other stronger nootropics.

How We Ranked

Our nootropic rankings are the result of hundreds of hours of research into dozens of products. Before we compiled our rankings, we only included products that are considered a “nootropic stack”, which requires several ingredients. Products that only list one ingredient are less likely to be effective so they were excluded immediately.

Once we had a list of nootropic stacks, we used a number of factors to rank our top nootropic products, including:

Product Formula:

We looked for products that contained several clinically studied ingredients. We looked for ingredients like DMAE, citicoline, bacopa, ginkgo biloba, and other proven ingredients.

We discounted products that mainly used caffeine for its’ cognitive benefits. While caffeine is a strong nootropic (hence why coffee is a staple product), you don’t need to bother with a nootropic if you just want to benefit from caffeine.

Finally, ingredient type is just as important as the dosage of each individual ingredient. Therefore, we looked for products with ingredient dosage as close to the dosage used in clinical studies because they are more likely to be effective.

Company Reputation:

Nootropics have actually been around for decades, but mainstream nootropics are still fairly new. Therefore, we wanted to make sure that we could trust the company behind the product.

We researched each company, how they manufacturer their products, what kind of guarantee they gave, and how well their customer support was. Companies with a better reputation and a longer history in the supplement industry were given preference over newer companies as we saw them as more trustworthy.

Likewise, a clear money back guarantee and multiple avenues to reach customer service were also preferred.

Product Reviews:

Our third and final metric for rating nootropic compounds was actual customer reviews. After all, a product can be seemingly dosed properly with the right ingredients but still come up short with users.

This is why we considered customer reviews. We looked for thorough reviews from actual customers to gauge their experience with a specific product. Did they feel the product was actually doing anything for them? Were there side effects? Would they recommend it to their friends or family? Did they feel the product was worth the money?

These are all questions we did our best to answer so we could truly identify the safest, strongest, and most effective nootropics.

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Benefits of Nootropics

Nootropics come in several different varieties. In general, they are designed to boost cognitive functions such as learning, memory, thinking, focus, and creativity. As such, most of the benefits of nootropics relate to these cognitive functions.

Testing out the benefits of nootropic ingredients is a fairly easy process too. Unlike products that promote “well-being”, you can clearly test cognitive function. Several studies give a group of subjects a placebo or a potential nootropic compound and then subject them to a number of tests to evaluate performance.

There are a variety of different tests performed to evaluate cognitive enhancement too. Learning tests are often the most common but other tests evaluate mental breakdown prevention and fatigue. Others include speech improvement and critical thinking.

The main four benefits of nootropics involve the improvement in focus, memory, critical thinking, and learning. However, there are some other benefits related to nootropics as well.

Nootropics may improve mood and reduce stress and anxiety.

Certain ingredients in nootropic supplements increase levels of neurotransmitters like serotonin, dopamine, and GABA in the brain. These neurotransmitters directly influence your mood, stress levels, and overall feeling on a daily basis. High levels of all three of these neurotransmitters are related to lower stress, better mood, and lower anxiety.

Nootropic compounds may provide cognitive protection.

Research dating back decades has evaluated herbal extracts for potential cognitive protection benefits. The most definitive study was conducted in 1999 involving huperzine-A.

In the study, older monkeys with naturally occurring dementia and younger monkeys with chemical induced cognitive decline were given huperzine A. Researchers were astounded to find that huperzine seemed to reverse the naturally occurring dementia in older monkeys and eliminated cognitive decline in the younger monkeys.

Human research is still scarce in this manner, but there’s plenty of anecdotal evidence to back up the animal research involving huperzine-A.

Nootropic supplements may reduce inflammation and oxidative stress in the brain.

The cause of brain inflammation isn’t entirely known outside of viral infections and other medical conditions. It is believed that the modern diet and lifestyle habits of the average adult likely plays a huge role.

Many nootropic supplements contain anti-inflammatory compounds to eliminate inflammation and protect the brain from further damage. Green tea extract and turmeric are the two most widely studied herbal extracts and are two of the most common anti-inflammatory compounds used in supplements nowadays. Cinnamon is another anti-inflammatory compound showing promising results in reducing inflammation caused cognitive decline.

Nootropic compounds can support brain health in a variety of ways. Which product you use depends entirely on your individual needs. It’s important you research a product and its’ ingredient profile so you know how effective a supplement could be to meet your individual needs and goals.

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Who Should Use Nootropics?

Nootropics are a unique type of supplement because virtually everyone can benefit from taking them. Entrepreneurs, students, employees, writers, engineers – virtually everybody can benefit from taking a nootropic supplement to enhance their cognitive ability.

It is true that different cognitive enhancers affect your brain in a different way and therefore may be best suited for specific individuals. For example, a college student is likely best suited for a nootropic supplement that enhances memory and focus to pass exams.

An engineer or an artist may want a nootropic that opens up the brain’s visual functioning and an elderly adult may want a product focused on restoring brain function and memory.

Realistically, anybody using their brain in a demanding way can benefit from a nootropic. While they are a fairly new type of supplement, there’s definitive proof cognitive enhancers can support a number of cognitively demanding tasks.

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Potential Side Effects & Adverse Effects

Interest in nootropics dates back over fifty years but unfortunately most nootropic supplements have only been around a few years. Although there’s more research into nootropic compounds, they are still too new for us to have a good understanding of their side effect profile.

The one nootropic compounds we do know understand is caffeine. Caffeine is the most widely studied nootropic compound in the world and we know it an effective energy and focus booster. It also can cause side effects like nausea and jitters when too much if you consume too much or you have a sensitivity to it.

For the most part, nootropics are well tolerated and do not possess any adverse effects to your health. However, this depends on the product and the individual ingredients used. You have to do your research and get a thorough understanding of the ingredients to make sure they are safe for you. If you are unsure, it is recommended you err on the side of caution and speak to your doctor before taking a nootropic supplement.

Recommended Dosage

There are dozens of ingredients in nootropic compounds and only a few have established effective doses. Ginkgo biloba is effective at as low as 40mg per day. Bacopa monnieri is effective at around 300-400mg per day.

DMAE is normally around a dose of 100mg but doses ranging from 50 to 200mg are common and all found some cognitive improvement in that range.

It’s incredibly difficult to identify optimal doses in most nootropic supplements. There is a tremendous amount of interest and research pouring into nootropic compounds, so it will only be a matter of time before we have a better idea of effective doses thankfully.

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Q. What is a nootropic?

A nootropic is a supplemental or pharmaceutical compound that improves any area of cognitive functioning. Cognitive function refers to any mental process involved in thinking, remembering, speaking, decision making, or problem solving, or creativity.

In other words, nootropics aid in critical thinking, memory, problem solving, focus, concentration, creativity, and other important brain functions.

Q. Are nootropics safe?

Since there are so many different vitamins, minerals, and herbal extracts found in nootropics, it is difficult to determine their safety on a broad, generalized manner. So far, nootropics do not appear to possess any common side effects or adverse reactions the way say, weight loss pills do.

However, anytime you include a number of ingredients from different sources, there’s a potential risk for side effects to occur.

In general, nootropics are seen as safe. There are a number of clinical studies available that have involved popular nootropic compounds like bacopa monnieri, ashwagandha, ginkgo biloba, and others. After a general review of these studies, there are no common side effects or serious health problems linked to these nootropic compounds. Reactions could still happen, but they seem to be very rare.

Q. Are there nootropics that mimic Adderall?

Adderall is a pharmaceutical compound (technically an amphetamine) that acts as a stimulant and overclocks the brain. It is commonly abused because of its’ ability to provide extreme focus and long-lasting energy.

It’s important to understand that Adderall is a pharmaceutical compound meant for specific individuals with certain conditions. Using Adderall outside its’ intended use can be very dangerous and overdoses happen on a regular basis.

There is one nootropic compound that can mimic Adderall and that’s caffeine. Caffeine is a fairly potent stimulant found in a variety of drinks, powders, pills, and snacks. It is one of the most widely studied compounds and is known to enhance memory, focus, energy, and concentration.

To sum it up, it is unwise to look for compounds that mimic Adderall because of the potency of Adderall and its’ potential side effects. If you want a stimulant that is safer and still has some of the same benefits as Adderall, then caffeine is a fairly safe choice.

Q. What’s the best nootropic?

It is virtually impossible to say what the best nootropic is because there are so many different individual compounds that each work in a unique manner.

For example, there’s plenty of evidence that ashwagandha and ginkgo biloba help enhance memory. On the other side, green tea extract and fish oil are two of the best natural neuroprotective nootropic compounds (to protect the brain).

What may be the best nootropic compound for you likely differs from someone else because of your individual goals. Therefore, the best nootropic supplement is the supplement with an ingredient formula designed to meet your individual goals.

Q. What do nootropics do?

Nootropics are meant to enhance your ability to think, remember, focus, and make decisions. Essentially, any cognitive function you have can be improved through nootropics.

They work in a variety of ways. Some ingredients like DMAE and tyrosine help support the function of neurotransmitters (brain chemicals) in the brain to improve brain function.

Other herbal extracts like green tea, turmeric, and ashwagandha reduce inflammation and oxidative stress in the brain that may be responsible for poor cognitive abilities.

Other nootropic compounds like caffeine are stimulants that improve energy levels and speed up the entire central nervous system.

Q. Are nootropics addictive?

Most nootropic compounds are not inherently addictive – at least nootropics you can buy over the counter.

The only real exception is caffeine, which is one of the most addictive compounds on the planet. Consuming excessive amounts of caffeine can cause caffeine withdrawal and lead to headaches, fatigue, and anxiety.

Nicotine is seen as a natural form of nootropic too and is another addictive substance. However, we haven’t found a nootropic supplement with nicotine so it’s mostly irrelevant if you’re looking for nootropics online or at your local store.

Aside from caffeine and nicotine, there aren’t any herbal extracts commonly used in nootropics that are known to be addictive.


Nootropics are a fairly new type of supplement but there’s already plenty of evidence that they can support cognition in several different ways.

Before you pick a nootropic, it’s important to think about what your individual needs are and to pick a nootropic supplement that fits your needs. A college student likely needs a nootropic geared towards memory and learning whereas someone who’s older likely needs a nootropic for cellular rejuvenation and restoration.

When done properly, nootropics appear to be a very effective & safe way to increase your overall cognition, improve your brain power, and help you work and think faster and more effectively.

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As you walk away from our comprehensive guide to the top nootropic dietary supplements of 2021, we want you to remember a few things. First, consider the various ways that we evaluated nootropic supplements to compile this list. Always look out for the key ingredients in a supplement before making your purchase. For example, nootropic formulas should include natural, quality ingredients. These ingredients should also be provided in sufficient quantities to provide observable results. Most nootropics must be taken consistently over an extended period of time in order to provide you with any serious results.

Also remember the viable benefits that the average nootropic can provide you with. The Limitless pill does not exist. Taking a pill will never make you a super-genius, and your reflexes will never become better after a simple supplement. However, many nootropic ingredients have been shown in landmark scientific studies to help improve memory in the short-term. Some pills and their ingredients have also been proven to increase overall brain function and cognitive capacity, all of which are classic indicators of overall intelligence.

There are side effects associated with some nootropic supplements, which makes this type of alternative formula a bit different than others on the market. Some nootropics contain high amounts of caffeine, as well as other stimulants. These ingredients can cause addiction and dependency. Additionally, some nootropic formulas can create withdrawal symptoms, violent behavior, and other problems. Some users might experience panic attacks or increased anxiety after taking a new nootropic. We frequently outline how most supplements don’t ultimately contribute to serious side effects, so we should highlight the unique negatives associated with some nootropics.

We included more in-depth information about the side effects associated with nootropics in some of the sections above. But as a closing statement, we’d like to recommend that readers carefully evaluate the ingredients present in a nootropic before purchasing it. People who have trouble sleeping, folks who have addictive personalities, and people who are pregnant should consider avoiding nootropics, which can make all of these existing conditions worse.

Despite the wealth of potential downsides to nootropics, we still ultimately recommend the use of nootropics for some people who want to improve their brain health and memory. Several of the nootropics ranked on our list have been carefully researched in major scientific studies. The benefits associated with these supplements are nothing compared to the incredible effects experienced by the protagonist in Limitless. But given the disaster that occured for the man in that movie, is that really such a bad thing?

Modern nootropics don’t offer the incredible benefit of super-intelligence or lightning fast reflexes, but they can do several important things for people who want to improve their memory and fast-track their cognitive development. As with all dietary supplements, the best route for consumers who want to avoid being scammed is to carefully read the ingredients on any formula they plan to take. After vetting your formula to be sure it is composed of non-addictive and natural ingredients, it might be time to give nootropics a shot!

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