Las Vegas, USA, July 19, 2021 (GLOBE NEWSWIRE) -- Lupus Nephritis Pipeline Experiences Momentum: DelveInsight Estimates a Diverse Lupus Pipeline Comprising a Broad Spectrum of Molecular Targets
Lupus Nephritis Pipeline encompasses promising therapies with an aim to meet the unmet need in the Lupus Nephritis treatment space.
DelveInsight’s ‘Lupus Nephritis Pipeline Insights’ report lays down a holistic coverage of the available therapies, Lupus Nephritis pipeline therapies in different phases of clinical development, key companies active in the Lupus Nephritis pipeline domain, drivers and barriers in the successful launch of the therapies and future trends.
Some of the notable pointers extracted from the Lupus Nephritis Pipeline report:
- DelveInsight’s analysis depicts a robust Lupus Nephritis Pipeline with 24+ active players in the domain working on 24+ pipeline therapies.
- Key Lupus Nephritis pipeline therapies such as AT-1501, Zanubrutinib, Secukinumab, NTR-441, Guselkumab, Obinutuzumab, BMS-986165, LABP-104, SHR-1314, Itolizumab, Ravulizumab, BI-655064, OMS721, Sirolimus, and others are under investigation in different phases of clinical trials for the treatment of Lupus Nephritis.
- Roche, Omeros Corporation, Novartis, BeiGene, Janssen Biotech, Bristol-Myers Squibb, Eledon Pharmaceuticals, Neutrolis Therapeutics, Landos Biopharma, Equillium, Suzhou Suncadia Biopharmaceuticals, Alexion Pharmaceuticals, Boehringer Ingelheim, North China Pharmaceutical Group among several others are some of the key prominent pharma players working in the domain.
- In August 2020, Roche initiated a Phase III randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of Obinutuzumab in patients with ISN/RPS 2003 Class III Or IV lupus nephritis. Results of the Phase II NOBILITY trial showed that obinutuzumab (Gazyva, Genentech) was well-tolerated with “no unexpected safety findings” by week 104.
- In June 2021, North China Pharmaceutical Group Corporation in collaboration with Peking Union Medical College Hospital are planning to initiate a Phase III, single-center, one-arm, open-label pilot study to investigate the efficacy of sirolimus for mild proteinuric flares in patients with Class III/IV±V lupus nephritis.
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The Lupus Nephritis Pipeline report covers the ongoing clinical trials, deals, mergers & acquisitions taking place in the domain, recent approvals and failures in space, and growth prospects across the Lupus Nephritis domain.
Lupus Nephritis Overview
Lupus Nephritis (LN), is one of the most severe organ manifestations of Systemic Lupus Erythematosus (SLE), which is an autoimmune disorder. The condition leads to the loss of immune tolerance of endogenous nuclear material resulting in systemic autoimmunity that causes damage to various tissues and organs.
Discover more about the disease, treatments, and pipeline therapies @ Lupus Nephritis Pipeline Assessment
Lupus Nephritis Pipeline Drugs
| Drug | Company | Phase | MoA | RoA |
| AT-1501 | Eledon Pharmaceuticals | Phase I | CD40 ligand inhibitors | Injectable |
| Zanubrutinib | BeiGene | Phase II | Agammaglobulinaemia tyrosine kinase inhibitors | Oral |
| Secukinumab | Novartis | Phase III | IL17A protein inhibitors | Subcutaneous |
| NTR-441 | Neutrolis Therapeutics | Preclinical | Extracellular trap inhibitors | NA |
| Guselkumab | Janssen Research & Development | Phase II | Interleukin-23 subunit p19 inhibitors | Intravenous |
| Obinutuzumab | Roche | Phase III | Antibody-dependent cell cytotoxicity | CD20 |
| LABP-104 | Landos Biopharma | Preclinical | LANCL2 agonist | Oral |
| Itolizumab | Equillium | Phase I | CD6 antigen inhibitors | Subcutaneous |
| BI-655064 | Boehringer Ingelheim | Phase II | CD40 antigen inhibitors | Subcutaneous |
| Nipocalimab | Janssen Research & Development | Phase II | Fc receptor antagonists | Intravenous |
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Lupus Nephritis Therapeutics Assessment
The Lupus Nephritis Pipeline report proffers an integral view of the Lupus Nephritis emerging novel therapies segmented by Stage, Product Type, Route of Administration, Molecule Type, Target, and Mechanism of Action.
By Product Type
- Mono
- Combination
By Stage
- Discovery
- Pre-clinical
- Phase I
- Phase II
- Phase III
By Molecule Type
- Small molecules
- Monoclonal antibodies
By Route of Administration
- Subcutaneous
- Intravenous
- Oral
- Injectable
By Mechanism of Action
- CD6 antigen inhibitors
- Agammaglobulinemia tyrosine kinase inhibitors
- CD40 ligand inhibitors
- Antibody-dependent cell cytotoxicity
- Interleukin-23 subunit p19 inhibitors
- LANCL2 agonist
- Interferon-alpha inhibitors
- IL17A protein inhibitors
- Extracellular trap inhibitors
By Targets
- IL17A protein
- CD20
- Agammaglobulinemia tyrosine kinase
- Complement C5
- MASP2 protein
- CD40 antigen
- Interleukin-23 subunit p19
- TYK2 kinase
- Complement C3
For rich insights into merging therapies and assessment, visit Lupus Nephritis Pipeline Emerging Novel Therapies
Scope of the Lupus Nephritis Drug Pipeline Report
Coverage: Global
Key Players: Roche, Omeros Corporation, Novartis, BeiGene, Janssen Biotech, Bristol-Myers Squibb, Eledon Pharmaceuticals, Neutrolis Therapeutics, Landos Biopharma, Equillium, Suzhou Suncadia Biopharmaceuticals, Alexion Pharmaceuticals, Boehringer Ingelheim, North China Pharmaceutical Group, among others.
Key Lupus Nephritis Pipeline Therapies: AT-1501, Zanubrutinib, Secukinumab, NTR-441, Guselkumab, Obinutuzumab, BMS-986165, LABP-104, SHR-1314, Itolizumab, Ravulizumab, BI-655064, OMS721, Sirolimus, and several others.
Discover more about the scope of the report @ Lupus Nephritis Emerging Therapies, Treatments, and Ongoing Clinical Trials
Table of Contents
| 1 | Report Introduction |
| 2 | Executive Summary |
| 3 | Lupus Nephritis Disease Overview |
| 4 | Lupus Nephritis Pipeline Therapeutics Comparative Analysis |
| 5 | Lupus Nephritis Therapeutic Assessment |
| 6 | In-depth Commercial Assessment |
| 7 | Lupus Nephritis – DelveInsight’s Analytical Perspective |
| 8 | In-depth Commercial Lupus Nephritis Assessment |
| 9 | Lupus Nephritis Collaboration Deals |
| 10 | Late Stage Lupus Nephritis Products (Phase III) |
| 11 | Mid-Stage Lupus Nephritis Products (Phase II) |
| 12 | Early Stage Lupus Nephritis Products (Phase I) |
| 13 | Pre-clinical and Discovery Stage Lupus Nephritis Products |
| 14 | Inactive Lupus Nephritis Pipeline Products |
| 15 | Key Lupus Nephritis Products |
| 16 | Unmet Needs |
| 17 | Lupus Nephritis Market Drivers and Barriers |
| 18 | Future Perspectives and Conclusion |
| 19 | Analyst Views |
| 20 | Key Lupus Nephritis Companies |
| 21 | Appendix |
Learn more about the report offerings @ Lupus Nephritis Pipeline Therapies and Emerging Trends
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