Purple Biotech Reports Fourth Quarter and Full-Year 2022 Financial Results


Expands pipeline with acquisition of new tri-specific antibodies
Data readouts for two lead clinical programs expected in 2023

REHOVOT, Israel, Feb. 08, 2023 (GLOBE NEWSWIRE) -- Purple Biotech Ltd. (“Purple Biotech” or “the Company”) (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class, effective and durable therapies that harness the power of the tumor microenvironment to overcome tumor immune evasion and drug resistance, today announced financial results for the year and the three months ended December 31, 2022.

“We are reporting our 2022 financial results which are in line with our plans,” said Gil Efron, Chief Executive Officer of Purple Biotech. “Our end-of-year balance sheet is strong and enables us to execute our strategic plan. We started 2023 by acquiring an innovative platform of tri-specific antibodies and we are looking forward to data readouts from both of our ongoing clinical programs. I believe that our diverse promising pipeline is a good foundation for building a strong and sustainable oncology company.

“During 2022 we enhanced the CM24 trial, reprioritizing its study arms and expanding the design to randomize the study – a good example of the thoughtful, flexible approach we take to drug development. For NT219 we advanced the dose escalation Phase 1 study, both as monotherapy and in combination with cetuximab, and have reached the 50mg/kg dose level in both arms. We anticipate reporting clinical data for both CM24 and NT219 during this coming year. We just completed the acquisition of Immunorizon, thus securing a valuable portfolio of multi-specific antibodies that are highly complementary to our existing clinical compounds targeting the tumor microenvironment.”

Business Development, Post-Fiscal 2022

  • Immunorizon Acquisition Expands Company Pipeline

    After the close of the 2022 fiscal year, Purple Biotech expanded its product pipeline through the acquisition of private company Immunorizon Ltd. This acquisition, signed on February 2, 2023, brings a portfolio of potential multi-specific T and NK cell engager oncology therapies that selectively activate the immune response within the tumor microenvironment. The lead asset targets the antigen 5T4, activating both T and NK cells to mount a powerful immune system response against cancer cells; importantly, the compound includes a cleavable capping technology that has the potential to widen the therapeutic index. The acquisition provides Purple Biotech with a technology platform for tri-specific antibody compounds and offers the potential to further expand to additional targets. The Company anticipates bringing the first of these assets to IND filing in approximately two years.

  • Collaboration with Mor Research Applications

    Also after the close of fiscal 2022, Purple Biotech announced on January 3, 2023, a research collaboration with Mor Research Applications, the technology transfer subsidiary of Clalit Healthcare Services. The agreement gives Purple first access to pre-clinical oncology product candidates owned by Mor, including the option to fund early development, in-license selected drug assets and pursue their development and commercialization.

Corporate Updates for 2022

Clinical Studies

  • CM24 Study Design Update (PDAC)

    The Company has amended the Phase 2 clinical trial evaluating the combination of its monoclonal antibody CM24, a potential new first-in-class mAb that blocks the immune checkpoint CEACAM1 from supporting tumor immune evasion and survival, with the PD-1 inhibitor (nivolumab) plus chemotherapy for patients with 2L metastatic pancreatic cancer (PDAC). The clinical trial design has been amended to randomize the study comparing CM24+nivolumab+standard-of-care (SoC) chemotherapy against SoC chemotherapy. The study is ongoing, with patients being treated in a run-in portion of the study, which includes up to 18 patients followed by approximately 60 patients in the randomized part of the study. An interim analysis is expected in the second half of 2023 and a topline report on the overall study at the end of 2024.

  • CM24 Presentation at AACR Special Conference

    At the American Association of Cancer Research (AACR) Special Conference: Cancer Metastasis in November, Purple Biotech presented data that provide a rationale for an innovative mechanism of action for CM24. “CM24, a Novel Anti-CEACAM1 mAb, Suppresses Neutrophil Extracellular Trap (NET)-Induced Migration and Metastasis of Cancer Cells” focused on the compound’s activity against neutrophil extracellular traps.

  • NT219 Study Progress (SCCHN)

    In the monotherapy arm of the Phase 1/2 clinical trial for NT219, participants are being treated at the 50 mg/kg dose level, which is the last dose to be evaluated for monotherapy treatment. In the combination arm of NT219 + cetuximab, we are now recruiting for the 50 mg/kg dose of NT219. As this trial progresses, Purple Biotech expects to reach the recommended Phase 2 dose (RP2D) this year and enter into the Phase 2 of this study thereafter.

Management Changes

  • In July, Gil Efron transitioned from serving as President and Chief Financial Officer to the Chief Executive Officer position when Isaac Israel stepped down as CEO, while retaining his membership on the Board of Directors and as an advisor to the Company. The Company also welcomed Lior Fhima as Chief Financial Officer in November.

Financial Results for the Year Ended December 31, 2022

Research and Development Expenses were $16.3 million, an increase of $4.5 million, or 38.1%, compared to $11.8 million in the same period of 2021. The increase was mainly due to expenses related to the ongoing NT219 and CM24 clinical trials, including CMC expenses.

Selling, General and Administrative Expenses were $6.3 million, compared to $6.1 million in the same period of 2021, an increase of $0.2 million.

Operating Loss was $22.6 million, an increase of $4.7 million, or 26.3%, compared to $17.9 million in the same period of 2021. The increase was mainly due to the increase in research and development expenses.

On a non-IFRS basis (as reconciled below), adjusted operating loss was $20.2 million, an increase of $4.3 million, compared to $15.9 million in the same period of 2021, mainly due to the increased expenses for clinical studies and manufacturing of drugs for these studies.

Net Loss for 2022 was $21.8 million, or $1.20 per basic and diluted share, compared to a net loss of $18.5 million, or $1.01 per basic and diluted share, in 2021. The increase in net loss was mainly due to $4.5 million in operating expenses, offset by a decrease of $0.6 million in loss from discontinued operation and an increase in finance income of $0.5 million. Adjusted net loss for the year was $19.6 million, an increase from $15.7 million in the full year of 2021.

As of December 31, 2022, Purple Biotech had cash and cash equivalents, short- and long-term deposits of $31.7 million, compared to $47.4 million on December 31, 2021. This cash position provides a cash runway into the second half of 2024.

During the year ended December 31, 2022, the Company sold, under the Open Market Sale Agreement with Jefferies LLC, approximately 543 thousand ADSs, at an average price of $2.65 per ADS. Net proceeds to the Company were approximately $1.3 million, net of issuance expenses.

Financial Results for the three Months Ended December 31, 2022

Research and Development Expenses were $4.8 million, an increase of $1.6 million, or 50%, compared to $3.2 million in the same period of 2021. The increase was mainly due to expenses related to the CM24 and NT219 clinical trials and CMC expenses.

Selling, General and Administrative Expenses were $1.8 million, compared to $1.5 million in the same period of 2021, an increase of $0.3 million.

Operating Loss was $6.6 million, an increase of $1.9 million, or 40.4%, compared to $4.7 million in the same period of 2021.

On a non-IFRS basis (as reconciled below), adjusted operating loss was $5.8 million, an increase of $1.4 million, compared to $4.4 million in the same period of 2021, mainly to increase in R&D expenses offset by other income.

Net Loss for the three months ended December 31, 2022 was $6.0 million, or $0.33 per basic and diluted share, compared to a net loss of $5.1 million, or $0.29 per basic and diluted, in the three months ended December 31, 2021. The increase in net loss was mainly due to an increase in R&D expenses offset by other income and increase in financial income. Adjusted net loss for the three months ended December 31, 2022 was $5.4 million, an increase from $4.4 million in the same period of 2021.

About Purple Biotech

Purple Biotech Ltd. (NASDAQ/TASE: PPBT) is a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance. The Company’s oncology pipeline includes NT219, CM24 and IM1240. NT219 is a dual inhibitor, novel small molecule that simultaneously targets IRS1/2 and STAT3. In a Phase 1/2 study of NT219, the Company is currently advancing it in a dose escalation as a monotherapy treatment of solid tumors, and in a dose escalation in combination with cetuximab for the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck (SCCHN) or colorectal adenocarcinoma (CRC). These studies will be followed by an expansion phase of NT219 at its recommended Phase 2 level in combination with cetuximab in patients with recurrent and metastatic SCCHN. CM24 is a humanized monoclonal antibody that blocks CEACAM1, an immune checkpoint protein that supports tumor immune evasion and survival through multiple pathways. The Company is advancing CM24 as a combination therapy with anti-PD-1 checkpoint inhibitors in a Phase 2 study for the treatment of pancreatic ductal adenocarcinoma (PDAC). The Company has entered into a clinical collaboration agreement with Bristol Myers Squibb for the Phase 2 clinical trials to evaluate the combination of CM24 with the PD-1 inhibitor nivolumab in addition to chemotherapy. IM1240 is a preclinical, conditionally-activated tri-specific antibody that engages both T cells and NK cells to mount a strong, localized immune response within the tumor microenvironment. The third arm specifically targets the Tumor Associated Antigen (TAA) 5T4 that is expressed in a variety of solid tumors and is correlated with advanced disease, increased invasiveness and poor clinical outcomes. IM1240 has a cleavable capping technology that confines the compound’s therapeutic activity to the local tumor microenvironment, and thereby potentially increases the anticipated therapeutic window in patients. The Company’s corporate headquarters are located in Rehovot, Israel. For more information, please visit https://purple-biotech.com/.

Forward-Looking Statements and Safe Harbor Statement

Certain statements in this press release that are forward-looking and not statements of historical fact are forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements that are not statements of historical fact, and may be identified by words such as “believe”, “expect”, “intend”, “plan”, “may”, “should”, “could”, “might”, “seek”, “target”, “will”, “project”, “forecast”, “continue” or “anticipate” or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect our current views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions, involve known and unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may cause our actual results, performance or achievements to be significantly different from any future results, performance or achievements expressed or implied by the forward-looking statements. Important factors that could cause or contribute to such differences include, among others, risks relating to: the expected benefits, synergies and costs of the transaction; management plans relating to the transaction; the potential future financial impact of the transaction; and any assumptions underlying any of the foregoing; the expected timing of the completion of the transaction and the parties’ ability to complete the transaction; the plans, strategies and objectives of management for future operations; product development for NT219 and CM24 as well as Immunorizon Ltd.’s portfolio of investigational tri-specific antibody compounds to be acquired; the process by which such early stage therapeutic candidates could potentially lead to an approved drug product is long and subject to highly significant risks, particularly with respect to a joint development collaboration; the fact that drug development and commercialization involves a lengthy and expensive process with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the expense, length, progress and results of any clinical trials; the impact of any changes in regulation and legislation that could affect the pharmaceutical industry; the difficulty in receiving the regulatory approvals necessary in order to commercialize our products; the difficulty of predicting actions of the U.S. Food and Drug Administration or any other applicable regulator of pharmaceutical products; the regulatory environment and changes in the health policies and regimes in the countries in which we operate; the uncertainty surrounding the actual market reception to our pharmaceutical products once cleared for marketing in a particular market; the introduction of competing products; patents obtained by competitors; dependence on the effectiveness of our patents and other protections for innovative products; our ability to obtain, maintain and defend issued patents; the commencement of any patent interference or infringement action against our patents, and our ability to prevail, obtain a favorable decision or recover damages in any such action; and the exposure to litigation, including patent litigation, and/or regulatory actions, and other factors that are discussed in our Annual Report on Form 20-F for the year ended December 31, 2021 and in our other filings with the U.S. Securities and Exchange Commission (“SEC”), including our cautionary discussion of risks and uncertainties under “Risk Factors” in our Registration Statements and Annual Reports. These are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those we have listed could also adversely affect us. Any forward-looking statement in this press release speaks only as of the date which it is made. We disclaim any intention or obligation to publicly update or revise any forward-looking statement or other information contained herein, whether as a result of new information, future events or otherwise, except as required by applicable law. You are advised, however, to consult any additional disclosures we make in our reports to the SEC, which are available on the SEC’s website, https://www.sec.gov.

CONTACTS:

Company Contact:
Lior Fhima
Chief Financial Officer
IR@purple-biotech.com

Media Inquiries:
Harriet Ullman
Vice President, Public Relations and Product Communications
LaVoieHealthScience
hullman@lavoiehealthscience.com

Purple Biotech Ltd.
Consolidated Unaudited Statements of Financial Positions
 
 As of December 31, 
 2022  2021 
 USD
thousands
  USD
thousands
 
      
Current assets     
Cash and cash equivalents 15,030   10,890 
Short term deposits 16,652   36,310 
Other investments 431   - 
Other current assets 1,143   1,273 
        
Total current assets 33,256   48,473 
        
Non-current assets       
Other investments -   187 
Right to use assets 467   619 
Fixed assets, net 215   277 
Long term deposits -   160 
Intangible assets 20,684   20,482 
        
Total non – current assets 21,366   21,725 
        
Total assets 54,622   70,198 
        
Current liabilities       
Lease liability -short term 194   199 
Accounts payable 2,132   1,473 
Other payables 4,732   2,578 
        
Total current liabilities 7,058   4,250 
        
Non-current liabilities       
        
Lease liability 321   550 
Post-employment benefit liabilities 145   292 
        
Total non-current liabilities 466   842 
        
Equity       
        
Share capital, no par value -   - 
Share premium 126,409   123,951 
Receipts on account of warrants 28,017   28,017 
Capital reserve for share based payment 10,164   8,862 
Capital reserve from transactions with related parties 761   761 
Capital reserve from hedging (6)  - 
Capital reserve from transactions with non-controlling interest (859)  (859)
Accumulated loss (117,575)  (95,905)
        
Equity attributable to owners of the Company 46,911   64,827 
Non-controlling interest 187   279 
        
Total equity 47,098   65,106 
        
Total liabilities and equity 54,622   70,198 
        


Purple Biotech Ltd.
Consolidated Unaudited Statements of Operations
 
 For the year ended  For the three months
ended
 
 December 31,  December 31, 
 2022  2021  2022  2021 
 USD
thousands
  USD
thousands
  USD
thousands
  USD
thousands
 
            
Revenues -   -   -   - 
                
Research and development expenses 16,320   11,827   4,820   3,245 
Sales, general and administrative expenses 6,283   6,107   1,781   1,494 
                
                
Operating loss 22,603   17,934   6,601   4,739 
                
Finance expenses 126   212   18   69 
Finance income (969)  (320)  (576)  (56)
                
Finance (income) expense, net (843)  (108  (558)  13 
                
Loss for the period from continuing operations 21,760   17,826   6,043   4,752 
                
Loss from discontinued operation -   642   -   354 
                
Loss for the period 21,760   18,468   6,043   5,106 
                
Other Comprehensive Loss:               
Items that will be transferred to profit or loss:               
Loss from cash flow hedges (6)  -   11   - 
                
Total comprehensive loss for the period 21,766   18,468   6,032   5,106 
                
Loss attributable to:               
Owners of the Company 21,668   18,384   6,011   5,072 
Non-controlling interests 92   84   32   34 
                
  21,760   18,468   6,043   5,106 
                
                
Total comprehensive loss attributable to               
Owners of the Company 21,674   18,384   6,000   5,072 
Non-controlling interests 92   84   32   34 
  21,766   18,468   6,032   5,106 
                
Loss per share date               
Continuing operations               
Basic and diluted loss per ADS - USD 1.20   1.01   0.33   0.44 
                
Number of ADSs used in calculation 18,081,087   17,568,036   18,389,230   17,733,554 
                
Discontinued operation  
   
Basic and diluted loss (profit) per ADS – USD -   0.04   -   0.02 
                
Number of ADSs used in calculation -   17,568,036   -   17,733,554 
                


Purple Biotech Ltd.
Consolidated Unaudited Statements of Cash Flow
 
  For the year ended  For the three months
ended
 
  December 31,  December 31, 
  2022  2021  2022  2021 
  USD
thousands
  USD
thousands
  USD
thousands
  USD
thousands
 
             
Cash flows from operating activities from continuing operation:            
Loss for the period from continuing operation  (21,760)  (17,826)  (6,043)  (4,752)
                 
Adjustments:                
Depreciation  201   231   50   61 
Finance expense (income), net  (843)  (108)  (558)  13 
Share-based payments  2,412   2,082   839   305 
                 
   (19,990)  (15,621)  (5,712)  (4,373)
                 
Changes in assets and liabilities:                
Changes in other current assets  313   (316)  437   (121)
Changes in accounts payable  799   266   (735)  (275)
Changes in other payables  2,132   573   1,637   1,199 
Changes in post-employment benefit liabilities  11   27   159   27 
                 
   3,255   550   1,498   830 
                 
Net cash used in operating activities from continuing operation  (16,735)  (15,071)  (4,214)  (3,543)
                 
Cash flows from investing activities from continuing operation:                
Acquisition of intangible asset  (202)  -   -   - 
Decrease in deposits  19,818   13,162   7,999   4,997 
Interest received  324   359   -   62 
Acquisition of fixed assets  (26)  (115)  -   - 
                 
Net cash provided by investing activities from continuing operation  19,914   13,406   7,999   5,059 
                 
Cash flows from financing activities from continuing operation:                
Proceeds from issuance of ADSs  1,498   564   186   564 
ADS issuance expenses paid  (152)  (24)  (38)  (23)
Proceeds from exercise of warrants  -   1,200   -   - 
Repayment of lease liability  (165)  (153)  (41)  (41)
Interest paid  (67)  (75)  (18)  (21)
                 
Net cash provided by financing activities from continuing operation  1,114   1,512   89   479 
                 



Purple Biotech Ltd.
Consolidated Unaudited Statements of Cash Flow (cont’d)
 
 
  For the year ended For the three months
ended
  December 31, December 31,
  2022  2021 2022 2021
  USD
thousands
  USD
thousands
 USD
thousands
 USD
thousands
          
Cash flows in respect of discontinued operation as follows:         
          
Net cash used in operating activities  -  (374) -  (374)
Net cash from investing activities  -  -  -  - 
Net cash from financing activities  -  -  -  - 
            
Net cash used in discontinued operation  -  (374) -  (374)
            
Net increase (decrease) in cash and cash equivalents  4,293  (333) 3,874  1,785 
Cash and cash equivalents at the beginning of the period  10,890  11,247  11,074  9,117 
Effect of translation adjustments on cash and equivalents  (153) (24) 82  (12)
            
Cash and cash equivalents at end of the period  15,030  10,890  15,030  10,890 
              


Purple Biotech Ltd.
Reconciliation of Non-IFRS financial Results
Reconciliation of Adjusted Operating Loss
 
  For the year ended For the three months
ended
  December 31, December 31,
  2022
 2021  2022  2021 
  USD thousands USD thousands USD thousands USD thousands
         
Operating loss for the year 22,603  17,934  6,601  4,739 
Less ESOP expenses (2,412) (2,082) (839) (305)
             
  20,191  15,852  5,762  4,434 


Reconciliation of Adjusted Net Loss
 
  For the year ended For the three months
ended
  December 31, December 31,
  2022  2021  2022  2021 
  USD thousands  USD thousands USD thousands  USD thousands
           
Net loss for the year 21,760  18,468  6,043  5,106 
Less warrant expenses -  -  -  - 
Less ESOP expenses (2,412) (2,082) (839) (305)
Less (loss) from discontinued operation -  (642) -  (354)
Less finance income from financial instruments 244  -  244  - 
           
  19,592  15,744  5,448  4,447