Opioids Market to Soar to USD 29.5 Billion by 2033 | Driven by Chronic Pain Prevalence and Increasing Surgical Procedures

Governments and regulatory bodies are implementing stricter regulations and controls on opioid prescribing practices to combat the opioid epidemic and reduce misuse, addiction, and overdose-related deaths. This includes initiatives such as prescription monitoring programs, prescribing guidelines, and restrictions on opioid formulations.

New York, Feb. 13, 2024 (GLOBE NEWSWIRE) -- According to Market.us, the Global Opioids Market size is projected to exceed USD 29.5 Billion by 2033, with a promising CAGR of 2.9% from 2024 to 2033.

The global opioids market was valued at USD 22.2 billion in 2023. A class of drugs derived from opium or synthetic versions, acting on nervous system to relieve pain is known as Opioids. These compounds mimic the effects of natural opium compounds and are commonly prescribed for the treatment of acute and chronic pain along with relieve of post-operative pain. The increasing demand for pain management medications has tremendously up surged the demand for opioids, thus propelling the market in the near future.

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Opioids Market Size

Key Takeaway

  • Along with pain management, opioids are also prescribed for the relieve of severe coughing and diarrhea.
  • Based on product, oxycodone segment leads the opioids market in 2023.
  • By application analysis, a large market shares of 39.5% is held by pain management segment.
  • Depending upon route of administration, injectable segment accounted highest revenue share, dominating the opioids market in 2023.
  • The implementation of stringent government regulations for opioid products can impede the market during the forecast period.

Factors Affecting the Growth of the Global Opioids Industry?

Several factors are affecting the growth of the Global Opioids market. These include:

  • Technological advancements: Sophisticated technologies have empowered pharmaceutical companies to develop exceptionally potent drugs, leading to the expansion of the opioids market.
  • High costs of research and development: The opioids market is limited by the high costs associated with the research and development process.
  • Shifting inclination towards preventive medicine: The use of herbal medicinal products as an additional treatment to prevent post-operative pain and severe diarrhea has gained popularity in recent times, which presents new opportunities for the market.
  • Demand for ideal products: The emergence of several opioids product assist in the better recovery of disease and pain management, thus fostering the opioids market.

Top Trends in the Global Opioids Market

The adoption of Fentanyl, a synthetic opioid approved for treating severe pain, such as advanced cancer pain has paved opportunistic pathways for the opioids market excellence. This medication is considered 50 to 100 times more potent than morphine, hence helping in better pain management. In addition to this, Protonitazene, a next generation opioid, is considered much more potent than Fenatyl. Thus, the emergence of advanced opioid medications in order to treat disease or manage severe pain has led to the enhancement of opioids market substantially.

Market Growth

Increase in product approval by the regulatory authorities and launch of new opioid medicines for the treatment of patients dealing with chronic pain are the main factors propelling the market growth. The major market players are thoroughly involved to make up new strategies in order to launch opioid product with least side effects and at affordable prices. In addition to this, the rise of geriatric population also provides a contributing hand in the upscale of the market. This rise in geriatric population is linked with declining fertility and mortality rates. In case of aged people above 65, there are more chances of dealing with chronic pain, thus fostering the market growth in upcoming years.

Regional Analysis

Owing to increasing acceptance of opioid based medications to comfort the growing medication need in the region, North America came up as the frontrunner in the global opioids market. The region is accounted to hold a remarkable market share of 26.8%, dominating the entire opioids market in 2023. In addition to this, the region is leveraged with large number of pharmaceutical companies and well maintained healthcare industry. On the other hand, the arrival of COVID 19 drastically affected the revenue share of the opioids market as all the necessary resources were shifted towards COVID 19 designated sites and intensive care units. Thus, the emergency outpatient chronic pain services were cut during COVID 19 pandemic.

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Opioids Market Region

Scope of the Report

Report AttributesDetails
Market Value (2023)USD 22.2 Billion
Forecast Revenue 2033USD 29.5 Billion
CAGR (2024 to 2033)2.9%
North America Revenue Share26.8%
Base Year2023
Historic Period2018 to 2022
Forecast Year2024 to 2033

Market Drivers

A large patient pool suffers from chronic pain; amongst them geriatric population lists out number one, as geriatric population are majorly associated with orthopedic pain. This act as a major factor driving the opioids market growth. Another crucial factor fueling the market size is the increase in demand for ideal products to treat pain, cough and diarrhea. Thus, these factors are anticipated to result a sky rocketing growth of the global opioids market.

Market Restraints

One of the most vital factor leading to increase in mortality rate is the death of patients due to opioid overdose. The up surge of opioid addiction among population can hamper the market growth in the upcoming years. Due to the associated risks with opioid addiction, the pharmaceutical companies and the retail pharmacies has to work in compliance with stringent regulatory requirements. Thus, these factors are projected to bring down the global opioids market in the near future.


With the increase in number of people suffering from chronic pain, the demand for ideal treatment products also upswings. For example, the production of cost-effective and accurate diagnostic methods for sepsis propels the market growth. Thus, the development of these novel biomarkers for sepsis diagnosis coupled with advancements in techniques boosts the market for opioid products. In addition to this, to meet the unmet need of patients suffering from severe diseases or pain, collaborations between government and private firms are made in order to develop accurate and cost effective diagnostic kits. Hence, these efforts lay many lucrative opportunities leading to the industrial growth and thus its market.

Impact of Macroeconomic Factors

One of the main export from India to Ukraine comprises of pharmaceutical products, as India is the third largest exporter of pharmaceuticals to Ukraine. From a pharma perspective, Russia and Ukraine are very crucial export markets, in which some of the Indian pharma companies have a very strong presence. But unfortunately, the conflict between Russia and Ukraine resulted a severe impact on Indian pharma industry, disrupting global trade, higher manufacturing and transportation costs, inflation and disruption of trade payment issues.

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Report Segmentation of the Global Opioids Market

By Product Analysis

Based on product, the global opioid market is segmented into Codeine, Methadone, Morphine and Oxycodone. The features such as long lasting effect coupled with extended release opioids makes the oxycodone segment to amount a large market share of 41.8%. In addition, Oxycodone and Hydrocodone are among the most common prescribed long acting drugs. To treat severe chronic pain in patients dealing with advanced stage cancer, Fentanyl is a common synthetic opioid prescribed to the patients.

By Application Analysis

With respect to applications, the market is bifurcated into pain management, diarrhea treatment, cough treatment and anesthesia. Amongst these, the pain management segment is accounted to capture a hefty market share of 39.5%, dominating the entire segment. The prominence of the segment owes to the fact that, increasing surgical operations up scale the demand for opioid medications to deal with post-operative pain.

Moreover, the anesthesia segment is anticipated to be the fastest growing segment in the global opioids market. During anesthesia, there is high use of intravenous opioids for the provision of analgesia and supplement sedation, thus increasing the demand for intravenous opioids, further fueling the market growth.

By Route of Administration Analysis

The worldwide opioid market is fragmented into injectable and orals depending upon the route of administration. Maintaining a commanding position in the market, the injectable segment held a large market share of 74.6%. The reason of the segment being prominent is the approval of new opioid injectable. To illustrate, the morphine sulphate injectable was approved by US FDA in April 2021. Thus, the approval of these opioid injectable significantly bolsters the market during the forecast period.

By Distribution Channel Analysis

By distribution channel, the market is broadly classified into retail pharmacies and hospital pharmacies. Owing to easy availability of medicines and high opioid dispensing rates, the retail pharmacy segment is accounted to hold a considerable market share of 61.4%, dominating the other segment in 2023.

Opioids Market Share

Recent Development of the Global Opioids Market

  • In August 2021: Esteve Pharmaceuticals (Celecoxib and Tramadol Hydrochloride) was approved by United States Food and Drug Administration. These medications help to manage severe acute pain in adults.
  • In January 2022: Trevena Inc announced that, a New Drug Application was approved by China’s National Medical Products Administration. The approval is for adult use to treat severe pain in United States.

Market Segmentation

By Product Type

  • Codeine
  • Methadone
  • Morphine
  • Oxycodone

By Application

  • Pain Management
  • Diarrhea Treatment
  • Cough Treatment
  • Anesthesia

By Route of Administration

  • Oral
  • Injectable

By Distribution Channel

  • Hospital Pharmacy
  • Retail Pharmacy

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By Geography

North America

  • The US
  • Canada
  • Europe
  • Germany
  • France
  • The UK
  • Spain
  • Italy
  • Russia
  • Netherland
  •  Rest of Europe


  • China
  • Japan
  • South Korea
  • India
  • Australia
  • New Zealand
  • Singapore
  • Thailand
  • Vietnam
  • Rest of APAC

Latin America

  • Brazil
  • Mexico
  • Rest of Latin America

Middle East & Africa

  • South Africa
  • Saudi Arabia
  • UAE
  • Rest of MEA

Competitive Landscape

The market leaders are working on a variety of approaches, including partnerships, product investments, mergers and acquisitions, etc.

Some of the major players include:

  • Purdue Pharma L.P.
  • Hikma Pharmaceuticals PLC
  • Johnson & Johnson Services, Inc.
  • Pfizer, Inc.
  • Sanofi
  • AbbVie Inc.
  • Sun Pharmaceutical Industries Ltd
  • Grünenthal
  • Other Key Players

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