Protherics PLC Notification of Major Interest in Shares London, UK; Brentwood, TN, US; 8 August 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that the following notification of interest in the ordinary share capital of the Company was received today from Aviva plc. 1. Reason for the notification (please tick the appropriate box or boxes) An acquisition voting rights X An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): CHANGE TO THE TOTAL NUMBER OF VOTING RIGHTS IN ISSUE 2. Full name of person(s) subject to the Aviva plc & its notification obligation: subsidiaries 3. Full name of shareholder(s) (if different from Registered Holder: 2.): BNY Norwich Union Nominees Limited 6,741,190* Chase GA Group Nominees Limited 17,297,355* Chase Nominees Limited 979,009* CUIM Nominee Limited 5,150,906* Vidacos Nominees Limited 70,303* BNP Paribas - London 636,429 Chase Nominees Limited 3,518,325 State Street Nominees Limited 9,577,375 Vidacos Nominees Limited 2,180,596 *denotes direct interest 4. Date of the transaction (and date on which the 6 August 2008 threshold is crossed or reached if different): 5. Date on which issuer notified: 8 August 2008 6. Threshold(s) that is/are crossed or reached: 12% to 13% Change at Combined Interest level 7. Notified details: A: Voting rights attached to shares Class/type Situation previous to Resulting situation after the trigger ing of shares the Triggering transaction transaction if possible using the Number of Number of Number of Number of voting % of voting ISIN CODE Shares Voting shares rights righ ts Rights Direct Direct Indirect Dire ct Indirect Ordinary Shares 40,890,879 40,890,879 30,238,763 30,238,763 15,912,725 8.88 % 4.68% GB0007029209 B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that % of financial date Conversion may be acquired if the voting instrument Period/ instrument is exercised/ rights Date converted. N/A Total (A+B) Number of voting rights % of voting rights 46,151,488 13.56% 8. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable : See Section 3 Proxy Voting: 9. Name of the proxy holder: See Section 3 10. Number of voting rights proxy holder will cease to hold: 11. Date on which proxy holder will cease to hold voting rights: 12. Additional Figures are based on a total number of voting information: rights of 340,417,123 / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END
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