Cheshire, UK -- (MARKET WIRE) -- April 10, 2007 --

                                Protherics PLC

                         6 monthly Block Listing Return
                     Approved Executive Share Option Scheme

London, UK; Brentwood, TN, US: 10 April 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that the following 6 monthly block listing return in
respect of the Company's Approved Executive Share Option Scheme has been lodged
with the FSA today, in accordance with Listing Rule 3.5.6.

Name of applicant:                                         Protherics PLC

Name of scheme:                                            Protherics PLC Approved Executive Share Option Scheme

Period of return:                           From:          9 October 2006         To:        8 April 2007

Balance under scheme from previous return:                 356,924

The amount by which the block scheme has been increased,   Nil
if the scheme has been increased since the date of the
last return:

Number of securities issued/allotted under scheme during   21,625

Balance under scheme not yet issued/allotted at end of     335,299

Number and class of securities originally listed and the   387,712 Ordinary Shares (date of admission: 8 April 2005)
date of admission

Total number of securities in issue at the end of the      339,169,625

                                    |  Ends  |

For further information please contact:


Nick Staples, Director of Corporate Affairs               +44 (0) 7919  480510

Julie Vickers, Company Secretary                          +44 (0)1928 518000

Financial Dynamics - press enquiries

London: Ben Atwell, Anna Keeble                           +44 (0) 20 7831 3113

New York: John Capodanno, Jonathan Birt                   +1 212 850 5600

Or visit

                      This information is provided by RNS
            The company news service from the London Stock Exchange