Cheshire, UK--(Marketwire - June 12, 2007) -

                                 Protherics PLC

                         Notification of PDMR Interests

London, UK; Brentwood, TN, US; 12 June 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, today announces that, on 11 June 2007, the following options
over ordinary shares in the Company ("Ordinary Shares") were granted under the
terms of the Protherics PLC Long Term Incentive Plan at an exercise price of 2
pence per share:

Name                       Position                                   Number of
                                                                        Options

Ian Scoular                Director of Business Development             136,170
Nicholas Staples           Director of Corporate Affairs                114,893
Sally Waterman             Director of Research & Development           136,170

In addition, the following options were granted on 11 June 2007 under the terms
of the Protherics PLC Deferred Bonus Plan at an exercise price of 2 pence per
share:

Name                       Position                                   Number of
                                                                        Options

                                                                             
Nicholas Staples           Director of Corporate Affairs                 42,553
Sally Waterman             Director of Research & Development            31,914

Following the above grant of options, the above Persons Discharging Managerial
Responsibility hold options over the following number of Ordinary Shares:

Ian Scoular                                            972,894
Nicholas Staples                                       549,163
Sally Waterman                                         660,373



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For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs                +44 (0) 7919  480510
Julie Vickers, Company Secretary                           +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                            +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                    +1 212 850 5600

Or visit  www.protherics.com


                      This information is provided by RNS
            The company news service from the London Stock Exchange