Protherics PLC announces Holding(s) in Company


Cheshire, UK--(Marketwire - July 26, 2007) -

                                 Protherics PLC

                   Notification of Major Interests in Shares



London, UK; Brentwood, TN, US: 26 July 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 24 July 2007, a notification of interest in
the ordinary share capital of the Company was received from AXA Investment
Managers UK Limited on behalf of AXA S.A. and its Group companies, in accordance
with the Transparency Obligations Directive.  Details of their interest are as
follows:




1. Reason for the notification (please tick the appropriate box or boxes)


An acquisition or disposal of voting rights                                    x

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights


Other (please specify):

2. Full name of person(s) subject to the           
notification obligation:                                          

AXA S.A., 25 Avenue Matignon, 75008 Paris and its
group of companies.


3. Full name of shareholder(s) (if different
from 2.):


4. Date of the transaction (and date on which                         
the threshold is crossed or reached if
different):

23 July 2007

5. Date on which issuer notified:                                     

24 July 2007

6. Threshold(s) that is/are crossed or reached:                           

10%

7. Notified details:




A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
                  transaction
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect


GB0007029209      33,389,110  33,389,110   340,879       340,879       34,627,202    0.10%     10.21%








B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.




Total (A+B)
Number of voting rights                           % of voting rights


     34,968,081                                              10.31%




8. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable :



             Name of Company/Fund                    Number of Shares         % of issued share capital


AXA UK Investment Co ICVC                                1,121,588               0.33062

UK Smaller Companies Fund
        Indirect

Sun Life Pensions Management Ltd                            11,250               0.00332
        Direct

Sun Life Unit Assurance Ltd                                 53,913               0.01589

FTSE All Share Tracker
        Direct

Sun Life Pensions Management                               275,716               0.08128

FTSE All Share Tracker
        Direct

AXA Framlington                                         15,013,453               4.42568

UK Select Ops
        Indirect

AXA Framlington                                         13,753,131               4.05416

Equity Income
        Indirect

AXA Framlington                                          1,267,498               0.37363

Health
        Indirect

AXA Framlington                                          1,692,599               0.49895

Managed Balanced
        Indirect

AXA Framlington                                            394,259               0.11622

BAE Systems Pensions Fund CIF Trustees
        Indirect

AXA Framlington                                            176,049               0.05190

BAE Systems 2000 Pensions Fund
        Indirect

Framlington onshore private clients                      1,152,375               0.33970
        Indirect

Framlington onshore private clients                         56,250               0.01658
        Indirect


                                  Total Direct             340,879               0.10048

                                Total Indirect          34,627,202              10.20745


                                         TOTAL          34,968,081              10.30793

Proxy Voting:
9. Name of the proxy holder:
10. Number of voting rights proxy holder will cease to hold:
11. Date on which proxy holder will cease to hold voting
rights:


12. Additional information:







                                   |  Ends  |





For further information please contact:


Protherics
Nick Staples, Director of Corporate Affairs                                     +44 (0) 7919  480510
Julie Vickers, Company Secretary                                                +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                                                 +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                                         +1 212 850 5600



Or visit  www.protherics.com


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