Protherics PLC announces Blocklisting Interim Review


Cheshire, UK--(Marketwire - August 9, 2007) -

                               Protherics PLC

                6 monthly Block Listing Return in respect of
                    6% unsecured convertible loan notes


London, UK; Brentwood, TN, US: 9 August 2007 - Protherics PLC 
("Protherics" or the "Company"), the international biopharmaceutical 
company focused on critical care and cancer, announces that the following 
6 monthly block listing return in respect of the Company's 6% unsecured 
convertible loan notes has been lodged with the FSA today, in accordance 
with Listing Rule 3.5.6.


Name of applicant:        Protherics PLC

Name of scheme:           Block Listing in respect of 6% Unsecured 
                          Convertible Loan Notes

Period of return:         From:   9 February 2006     To:    8 August 2007

Balance under scheme      8,917,396 Ordinary Shares (Loan Notes to the 
from previous return:     value of GBP2,229,349.00)

The amount by which the 
block scheme has been 
increased, if the scheme 
has been increased since 
the date of the last 
return:                   Nil

Number of securities 
issued/allotted under 
scheme during             78,236 Ordinary Shares (Loan Notes to the value
period:                   of GBP19,559.00)

Balance under scheme not 
yet issued/allotted at    8,839,160 Ordinary Shares (Loan Notes to the 
end of period             value of GBP2,209,790.00

Number and class of 
securities originally     17,092,476 Ordinary Shares (Loan Notes to the
listed and the date of    value of GBP4,273,119.00) admitted on 8 
admission                 February 2005

Total number of securities in issue at the end of the period 

339,243,653 Ordinary Shares


                                   |  Ends  |


For further information please contact:

Protherics
Nick Staples, Director of Corporate Affairs         +44 (0) 7919  480510
Julie Vickers, Company Secretary                    +44 (0)1928 518000

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble                     +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt             +1 212 850 5600

Or visit  www.protherics.com


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