Cheshire, UK--(Marketwire - August 21, 2007) -

                                 Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 21 August 2007 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that on 20 August 2007, in accordance with the
Transparency Obligations Directive, a notification of interest in the ordinary
share capital of the Company was received from AXA Investment Managers UK
Limited on behalf of AXA S.A. and its Group companies ("AXA").  The notification
follows an increase in the Indirect voting rights of AXA from 10.94% to 11.01%
of total voting rights.  Details of their interest are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

An acquisition of voting rights                                          X

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the           AXA S.A., 25 Avenue Matignon, 75008 Paris and its
notification obligation:                                          group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which                        19 August 2007
the threshold is crossed or reached if

5. Date on which issuer notified:                                    20 August 2007

6. Threshold(s) that is/are crossed or reached:                           11%

7. Notified details:

A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect

0702920           37,631,294  37,631,294   345,879       345,879       37,346,514    0.10%     11.01%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.

Total (A+B)

Number of voting rights                           % of voting rights

37,692,393                                        11.11%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :

    Name of Company/Fund                             Number of Shares         % of issued share capital

AXA UK Investment Co ICVC                                1,121,588            0.33061
UK Smaller Companies Fund

Sun Life Pensions Management Ltd                            16,250            0.00479

Sun Life Unit Assurance Ltd                                 53,913            0.01589
FTSE All Share Tracker

Sun Life Pensions Management                               275,716            0.08127
FTSE All Share Tracker

AXA Framlington                                            727,476            0.21444
SEI UK Equity

AXA Framlington                                          1,879,667            0.55408
Throgmorton Trust

AXA Framlington                                         15,013,453            4.42557
UK Select Ops

AXA Framlington                                         13,753,131            4.05406
Equity Income

AXA Framlington                                          1,692,599               0.49893
Managed Balanced

AXA Framlington                                          1,379,667               0.40669
UK Smaller Companies

AXA Framlington                                            394,259               0.11622
BAE Systems Pensions Fund CIF Trustees

AXA Framlington                                            176,049               0.05189
BAE Systems 2000 Pensions Fund

Framlington onshore private clients                      1,152,375               0.33969

Framlington onshore private clients                         56,250               0.01658

                                  Total Direct             345,879               0.10196
                                Total Indirect          37,346,514              11.00876
                                         TOTAL          37,692,393              11.11071

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting

12. Additional information:

                                      |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs   +44 (0) 7919  480510
Julie Vickers, Company Secretary                +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Anna Keeble               +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt            +1 212 850 5600

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