TopoTarget A/S Symbion Fruebjergvej 3 DK 2100 Copenhagen Denmark Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com To the OMX Investor News No. 02-07 / Copenhagen, 11 October 2007 TopoTarget strengthens sales and marketing organisation Copenhagen, Denmark - 11 October 2007 - TopoTarget A/S (OMX:TOPO) has announced the further strengthening of its sales and marketing organisation following the launch of Savene™ and Totect™ on the European and US markets in 2006 and 2007 respectively. From today, John Parsons is appointed Chief Commercial Officer, with responsibility for developing TopoTarget's sales and marketing efforts in both Europe and the US. John joined the company in 2006 and has been instrumental in building up the sales force in the US and has been integral in the structuring of TopoTarget's ongoing sales effort in Europe. John has over 30 years commercial experience in building marketing and sales infrastructures for both pharmaceutical and biotech companies. “I am proud that TopoTarget has such an experienced and talented team with a comprehensive range of expertise in our different operational areas. John Parson's new role enables us to strengthen our global market focus and allows us to optimise our opportunities in sales and marketing so that we can continue to build a business providing value for patients and stakeholders,” said Peter Buhl Jensen, CEO of TopoTarget. Today's announcement does not change TopoTarget's full-year financial guidance for 2007. TopoTarget A/S For further information, please contact: Dr. Peter Buhl Jensen Telephone +45 39 17 83 41 Chief Executive Officer Mobile +45 21 60 89 22 Ulla Hald Buhl Mobile +45 21 70 10 49 Director of IR and Communications Background information About TopoTarget TopoTarget (OMX: TOPO) is a biotech company, headquartered in Denmark and with subsidiaries in US, Switzerland, Germany and the UK, dedicated to finding ''Answers for cancer'' and developing improved cancer therapies. TopoTarget is founded and run by clinical cancer specialists and combines years of hands-on clinical experience with in-depth understanding of the molecular mechanisms of cancer. Focus lies on highly predictive cancer models and key cancer targets (including HDACi, NAD+, mTOR, FASligand and topoisomerase II inhibitors) and a strong development foundation has been built. TopoTarget has a broad portfolio of small molecule pre-clinical drug candidates and eight drugs (both small molecules and protein based) are in clinical development, including both novel anti-cancer therapeutics and new cancer indications for existing drugs. Savene™/Totect™ was approved by EMEA in 2006 and the FDA in 2007 and is TopoTarget's first product on the market. For more information, please refer to www.topotarget.com. TopoTarget Safe Harbour Statement This announcement may contain forward-looking statements, including statements about our expectations of the progression of our preclinical and clinical pipeline including the timing for commencement and completion of clinical trials and with respect to cash burn guidance. Such statements are based on management's current expectations and are subject to a number of risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. TopoTarget cautions investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors, including, but not limited to, the following: The risk that any one or more of the drug development programs of TopoTarget will not proceed as planned for technical, scientific or commercial reasons or due to patient enrolment issues or based on new information from non-clinical or clinical studies or from other sources; the success of competing products and technologies; technological uncertainty and product development risks; uncertainty of additional funding; TopoTarget's history of incurring losses and the uncertainty of achieving profitability; TopoTarget's stage of development as a biopharmaceutical company; government regulation; patent infringement claims against TopoTarget's products, processes and technologies; the ability to protect TopoTarget's patents and proprietary rights; uncertainties relating to commercialization rights; and product liability expo-sure; We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, unless required by law.