Cheshire, UK--(Marketwire - December 20, 2007) -

                                 Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US; 20 December 2007 - Protherics PLC ("Protherics"
or the "Company"), the international biopharmaceutical company focused on
critical care and cancer, announces that the following notification of interest
in the ordinary share capital of the Company was received on 19 December 2007
from Legal & General Investment Management Ltd.

1. Reason for the notification (please tick the appropriate box or boxes)       N/A

    (see additional information)

An acquisition of voting rights                                                 x

An acquisition or disposal of financial instruments which may result in the acquisition
of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):___________________________________________

2. Full name of person(s) subject to the                      Legal & General Group Plc (L&G)
notification obligation:

3. Full name of shareholder(s) (if different from     Legal & General Assurance (Pensions Management) Limited
2.):                                                                       (PMC)

4. Date of the transaction (and date on which the                    12 December 2007
threshold is crossed or reached if different):

5. Date on which issuer notified:                                    19 December 2007

6. Threshold(s) that is/are crossed or reached:                     From 3% - 4% (L&G)

7. Notified details:

A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering
if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect

Ord 0.02          10,762,183  10,762,183   13,681,982    13,681,982                  4.02%

B: Financial Instruments
Resulting situation after the triggering transaction
Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.

Total (A+B)
Number of voting rights                           % of voting rights

                   13,681,982                                               4.02%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments
are effectively held, if applicable :

Legal & General Group Plc (Direct and Indirect) (Group)

Legal & General Investment Management (Holdings) Limited
(LGIMH) (Direct and Indirect)

Legal & General Investment Management Limited (Indirect) (LGIM)

            Legal & General Group Plc (Direct) (L&G) (13,681,982 - 4.02% = LGAS, LGPL & PMC)

Legal & General Investment Management (Holdings)              Legal & General Insurance Holdings Limited
Limited (Direct) (LGIMHD) (12,181,468 - 3.58% = PMC)          (Direct) (LGIH)

Legal & General Assurance (Pensions Management)               Legal & General Assurance Society Limited
Limited (PMC) (12,181,468 - 3.58% = PMC)                      (LGAS & LGPL)

                                                              Legal & General Pensions Limited (Direct)

Proxy Voting:
9. Name of the proxy holder:                                                       N/A

10. Number of voting rights proxy holder will cease to hold:                       N/A

11. Date on which proxy holder will cease to hold voting rights:                   N/A

12. Additional information:

                                                Notification using the total voting rights figure of

                                             Please note this notification has been delayed due to the
                                            large number of disclosures required following a substantial
                                            amount of new business which has come to Legal & General in
                                                         the form of an in-specie transfer.

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs                                    +44 (0) 7919  480510
Julie Vickers, Company Secretary                                                +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                                                   +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                                         +1 212 850 5600

Or visit

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            The company news service from the London Stock Exchange