Cheshire, UK--(Marketwire - January 22, 2008) -

                              Protherics PLC

                   Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 22 January 2008 - Protherics PLC ("Protherics" or
the "Company"), the international biopharmaceutical company focused on critical
care and cancer, announces that, on 21 January 2008, in accordance with the
Transparency Obligations Directive, a notification of interest in the ordinary
share capital of the Company was received from AXA Investment Managers UK
Limited on behalf of AXA S.A. and its Group Companies ("AXA").  Details of the
notification are as follows:

1. Reason for the notification (please tick the appropriate box or boxes)

A disposal of voting rights                                                    X

An acquisition or disposal of financial instruments which may result in the
acquisition of shares already issued to which voting rights are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the           AXA S.A., 25 Avenue Matignon, 75008 Paris and its
notification obligation:                                          group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which                       17 January 2008
the threshold is crossed or reached if

5. Date on which issuer notified:                                   18 January 2008

6. Threshold(s) that is/are crossed or reached:                           13%

7. Notified details:

A: Voting rights attached to shares
Class/type of     Situation previous to    Resulting situation after the triggering transaction
shares            the Triggering

if possible using Number of   Number of    Number of     Number of voting rights     % of voting rights
the ISIN CODE     Shares      Voting       shares
                              Rights       Direct        Direct        Indirect      Direct    Indirect

0702920           49,639,830  49,639,830   741,666       741,666       43,053,507    0.22%     12.66%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial    Expiration date Exercise/ Conversion      Number of voting rights    % of voting rights
instrument                           Period/ Date              that may be acquired if
                                                               the instrument is
                                                               exercised/ converted.

Total (A+B)

Number of voting rights                           % of voting rights

43,795,173                                              12.87%

8. Chain of controlled undertakings through which the voting rights and/or the financial instruments are
effectively held, if applicable :

         Name of Company/Fund                         Number of Shares       % of issued share capital

AXA UK Investment Co ICVC                                  546,090               0.16052
UK Smaller Companies Fund

Sun Life Pensions Management Ltd                            25,000               0.00735

Sun Life Unit Assurance Ltd                                 53,913               0.01585
FTSE All Share Tracker Life

Sun Life Pensions Management                               294,874               0.08668
FTSE All Share Tracker Pension

AXA Framlington                                            750,000               0.22046
SEI UK Equity

AXA Framlington                                          1,600,000               0.47031
St James Place Exempt (Pens) Fund

AXA Framlington                                          1,800,000               0.52910
St James Place Net (Life) Fund

AXA Framlington                                            400,000               0.11758
St James Place Offshore Fund

AXA Framlington                                            600,000               0.17637
Daimler Chrysler

AXA Framlington                                          3,120,333               0.91720
Throgmorton Trust

AXA Framlington                                         15,013,453               4.41308
UK Selet Ops

AXA Framlington                                         13,753,131               4.04262
Equity Income

AXA Framlington                                          2,000,000               0.58788
Managed Balanced

AXA Framlington                                          1,500,000               0.44091
UK Smaller Companies

AXA Framlington                                            500,000               0.14697
BAE Systems Pensions Fund CIF Trustees

AXA Framlington                                            220,000               0.06467
BAE Systems 2000 Pensions Fund

Framlington onshore private clients                        975,500               0.28674

Axa Sun Life With Profits Passive                          226,817               0.06667

Axa Sun Life With Profits Passive                          141,062               0.04146

AXA Framlington                                            275,000               0.08083
St James Place Internal Equity & Income UT

                                      Total Direct         741,666               0.21801
                                    Total Indirect      43,053,507              12.65523

                                             TOTAL      43,795,173              12.87324

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting

12. Additional information:

                                   |  Ends  |

For further information please contact:

Nick Staples, Director of Corporate Affairs               +44 (0) 7919  480510
Julie Vickers, Company Secretary                          +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                             +44 (0) 20 7831 3113
New York: John Capodanno, Jonathan Birt                   +1 212 850 5600

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