Notice of AGM


1. Annual General Meeting on 12 March 2008

The ordinary Annual General Meeting will be held on

              Wednesday 12 March 2008 at 4.30 pm (CET)

at Radisson SAS, Falkoner Centret, Falkoner Allé 9, 2000
Frederiksberg, Denmark.

The notice for the Annual General Meeting is enclosed.

2. Proposed change in members of the Board of Directors
At the Annual General Meeting on 12 March 2008 all board members
elected by the Annual General Meeting are up for election. The Board
of Directors proposes re-election of the following
shareholder-elected board members: Sten Scheibye, Göran A Ando, Kurt
Briner, Henrik Gürtler, Kurt Anker Nielsen and Jørgen Wedel.

Niels Jacobsen, who has been board member since November 2000, has
decided not to seek re-election.

The Board of Directors of Novo Nordisk A/S proposes that Pamela J
Kirby is elected to the Board of Directors at the Annual General
Meeting. For further information on Pamela J Kirby's background and
the motivation for her election, please see the notice for the Annual
General Meeting 2008 (enclosed) or the Company's website
novonordisk.com under 'About Novo Nordisk' - 'Corporate governance'.

Novo Nordisk is a healthcare company and a world leader in diabetes
care. In addition, Novo Nordisk has a leading position within areas
such as haemostasis management, growth hormone therapy and hormone
replacement therapy. Novo Nordisk manufactures and markets
pharmaceutical products and services that make a significant
difference to patients, the medical profession and society. With
headquarters in Denmark, Novo Nordisk employs approximately 26,000
employees in 80 countries, and markets its products in 179 countries.
Novo Nordisk's B shares are listed on the stock exchanges in
Copenhagen and London. Its ADRs are listed on the New York Stock
Exchange under the symbol 'NVO'. For more information, visit
novonordisk.com.

Further information:


Media:                 Investors:

Outside North America: Outside North America:
Mike Rulis             Mads Veggerby Lausten
Tel: (+45) 4442 3573   Tel: (+45) 4442 7945
mike@novonordisk.com   mlau@novonordisk.com

                       Hans Rommer
                       Tel: (+45) 4442 4765
                       hrmm@novonordisk.com

In North America:      In North America:
Sean Clements          Christian Qvist Frandsen
Tel: (+1) 609 514 8316 Tel: (+1) 609 919 7937
secl@novonordisk.com   cqfr@novonordisk.com



Stock Exchange Announcement no 11 /
2008


Appendix to Novo Nordisk A/S'  AGM Stock Exchange Announcement  dated
20 February 2008
To the shareholders of Novo Nordisk A/S

The Company will conduct its Annual General Meeting on

              Wednesday 12 March 2008 at 4.30 pm (CET)

at  Radisson   SAS,  Falkoner   Centret,   Falkoner  Allé   9,   2000
Frederiksberg, Denmark.

Agenda:
1.        The  Board  of  Directors' oral  report  on  the  Company's
activities in the past financial year.
2.     Presentation and  adoption of the audited Annual Report  2007,
including approval of the remuneration of the Board of Directors.
3.     A resolution to distribute the profit according to the adopted
Annual Report 2007.
4.     Election of members to the Board of Directors.
         All board members elected by the Annual General Meeting  are
up for election. The Board  of Directors proposes re-election of  the
following  current  board  members  elected  by  the  Annual  General
Meeting: Sten Scheibye,  Göran A Ando,  Kurt Briner, Henrik  Gürtler,
Kurt Anker Nielsen and Jørgen Wedel. The Board of Directors  proposes
that Pamela J Kirby is elected to the Board of Directors.
5.     Election of auditor.
         The   Board   of    Directors   proposes   re-election    of
PricewaterhouseCoopers.
6.     Proposals from the Board of Directors:
6.1   Reduction of the Company's B share capital from DKK 539,472,800
to DKK 526,512,800 by  cancellation of 12,960,000 B  shares of DKK  1
each from the Company's own holdings  of B shares at a nominal  value
of DKK 12,960,000,  equal to  2% of  the total  share capital.  After
implementation of the  share capital reduction,  the Company's  share
capital will amount to DKK  634,000,000 divided into A share  capital
of DKK 107,487,200 and B share capital of DKK 526,512,800.
6.2   Authorisation of the Board of Directors, until the next  Annual
General Meeting, to allow the Company to acquire own shares of up  to
10% of the share capital and at  the price quoted at the time of  the
purchase with a deviation of up to  10%, cf Article 48 of the  Danish
Public Limited Companies Act.
6.3   Donation to the World Diabetes Foundation (WDF) of an amount up
to a total  of DKK 575  million to be  granted in the  course of  the
financial years 2008-2017.
6.4       Adoption   of  proposed   guidelines  for   incentive-based
remuneration for the Board of Directors and Executive Management.
6.5   Amendments to the Articles of Association:
6.5.1 Article 4.2  and Articles 9.2-9.3:  Reduction of the  specified
minimum nominal value of  the Company's shares from  DKK 1.00 to  DKK
0.01 and a consequent amendment of the voting rights attached to  the
shares, following which every B share capital amount of DKK 0.01 (the
minimum nominal denomination) shall carry one vote and every A  share
capital amount of DKK 0.01  (the minimum nominal denomination)  shall
carry 10 votes.
6.5.2 Article 6.3: Existing authorisation  of the Board of  Directors
to issue  B  shares  to employees  without  pre-emptive  subscription
rights for existing shareholders to  be extended until 12 March  2013
and to be reduced to a maximum nominal amount of DKK 4 million.
6.5.3 Articles  6.4-6.6:  Existing  authorisations of  the  Board  of
Directors to  increase  the  share  capital  to  be  replaced  by  an
authorisation of  the  Board of  Directors  until 12  March  2013  to
increase the share capital by an amount up to a maximum of  nominally
DKK 126 million.
6.5.4 Article 7.2: Change of the specified venue for general meetings
to the Capital Region of Denmark.
6.5.5 Article  7.4: Reduction  of the  number of  shares required  to
request an extraordinary  general meeting  from 1/10 to  1/20 of  the
share capital.
7.     Miscellaneous.

Elaboration and statement explaining the proposals:

Re agenda item 3:
The proposed dividend for  2007 is DKK 4.50  for each Novo Nordisk  B
share of DKK 1.00 and for each Novo Nordisk A share of DKK 1.00. This
is a 29% increase compared to  the dividend for the fiscal year  2006
(DKK 7 for  each share of  DKK 2). No  dividend will be  paid on  the
Company's holding of treasury shares.

Re agenda item 4:
Novo Nordisk  A/S  is  aiming  at  composing  a  Board  of  Directors
consisting of persons who have such knowledge and experience that the
collective Board  of Directors  can attend  to the  interests of  the
Company and thus the interests  of the shareholders with due  respect
to other stakeholders of  the Company in the  best possible way.  The
Board of Directors actively contributes to developing the Company  as
a globally operating, focused pharmaceutical company, and  supervises
the management in its decisions and operations.
Please see the  Company's website novonordisk.com  under 'About  Novo
Nordisk' ®'Corporate governance' for  a more detailed description  of
the competence criteria of the Board of Directors.
The Board of Directors proposes re-election of the following  current
board members elected by the  Annual General Meeting: Sten  Scheibye,
Göran A Ando,  Kurt Briner,  Henrik Gürtler, Kurt  Anker Nielsen  and
Jørgen Wedel. The Board of Directors proposes that Pamela J Kirby  is
elected to the Board of Directors.
It is the  assessment of  the Board  of Directors  that the  proposed
composition  of   the   Board   of  Directors   complies   with   the
above-mentioned criteria.
In  addition  to  their  professional  qualifications,  the  proposed
candidates possess  significant experience  from the  daily work  and
management  of  international   pharmaceutical  and   high-technology
companies and together they have  the knowledge and the  professional
and international experience which  are competences important to  the
work of the Board of Directors.
The  proposed  board  candidates  have  the  following   backgrounds.
Independence is  defined  in  accordance with  the  Danish  Corporate
Governance Recommendations (2005) designated  by OMX Nordic  Exchange
Copenhagen (OMX) unless otherwise stated:

Sten Scheibye is chairman of the  Board of Directors of Novo  Nordisk
A/S. Since 1995,  he has  been president  and CEO  of Coloplast  A/S,
Denmark.
Besides being a member of the boards of various Coloplast  companies,
Mr Scheibye is  a member of  the Board of  Danske Bank A/S,  Denmark.
Furthermore, he holds a seat on  the Central Board and the  Executive
Committee of the Confederation of Danish Industries.
Mr Scheibye has an MSc in Chemistry  and Physics from 1978 and a  PhD
in Organic Chemistry from 1981,  both from the University of  Aarhus,
Denmark, and a  BComm from the  Copenhagen Business School,  Denmark,
from 1983.  Mr  Scheibye is  also  an adjunct  professor  of  applied
chemistry at the University of Aarhus.
Mr Scheibye was elected to the Board of Novo Nordisk A/S in 2003  and
has been re-elected several times, most recently in 2007. His term as
a board member expires in March 2008.
Mr Scheibye is regarded as an independent board member.
The special competences possessed by  Mr Scheibye that are  important
for the performance of his duties are his knowledge of the healthcare
industry, particularly as relates to patients requiring chronic care,
and managerial skills relating to international organisations.
Mr Scheibye is a Danish national, born on 3 October 1951.

Göran A Ando, MD, is vice-chairman of the Board of Directors of  Novo
Nordisk A/S. Dr Ando was CEO  of Celltech Group plc, UK, until  2004.
He joined  Celltech from  Pharmacia,  now Pfizer,  US, where  he  was
executive  vice  president  and  president  of  R&D  with  additional
responsibilities for manufacturing, IT, business development and  M&A
from 1995 to 2003.
From 1989 to 1995, Dr Ando was medical director, moving to deputy R&D
director and then  R&D director  of Glaxo Group,  UK. He  was also  a
member of the Glaxo Group Executive Committee.
Dr Ando is a specialist in general medicine and a founding fellow  of
the American College  of Rheumatology in  the US. Dr  Ando serves  as
chairman of the boards of Novexel SA, France, and Inion Oy,  Finland,
as vice-chairman of the Board of  S*Bio Pte Ltd, Singapore, and as  a
board  member  of  Novo  A/S,  Denmark,  Bio*One  Capital  Pte   Ltd,
Singapore, A-Bio Pharma Pte Ltd,  Singapore, NicOx SA, France,  Enzon
Pharmaceuticals, Inc, US, and EUSA Pharma, UK.
Dr  Ando  qualified  as  a   medical  doctor  at  Linköping   Medical
University, Sweden, in 1973 and  as a specialist in general  medicine
at the same institution in 1978.
Dr Ando was  elected to the  Board of  Novo Nordisk A/S  in 2005  and
re-elected in 2006 and  2007. His term as  a board member expires  in
March  2008.  Dr   Ando  is  designated   Research  and   Development
Facilitator by the Board of Novo Nordisk A/S.
Dr Ando is  not regarded as  an independent board  member due to  his
membership of the Board of Novo A/S.
The special competences possessed by  Dr Ando that are important  for
the performance  of his  duties are  his medical  qualifications  and
extensive   executive    background    within    the    international
pharmaceutical industry.
Dr Ando is a Swedish national, born on 6 March 1949.

Kurt Briner works as an independent consultant to the  pharmaceutical
and  biotech  industries  and  is  a  board  member  of  OM   Pharma,
Switzerland, Progenics  Pharmaceuticals  Inc, US,  and  GALENICA  SA,
Switzerland. From 1988 to  1998, he was president  and CEO of  Sanofi
Pharma, France. He has  been chairman of  the European Federation  of
Pharmaceutical Industries and Associations (EFPIA).
Mr Briner holds  a Diploma  of the  Commercial Schools  of Basel  and
Lausanne, Switzerland.
Mr Briner was elected to  the Board of Novo  Nordisk A/S in 2000  and
has been re-elected several times, most recently in 2007. His term as
a board member expires in March 2008.
Mr Briner is regarded as an independent board member.
The special competences possessed by Mr Briner that are important for
the performance  of  his  duties are  his  executive  background  and
knowledge of the pharmaceutical and biotech industries as well as  of
global,  particularly   European   pharmaceutical   regulations   and
policies.
Mr Briner is a Swiss national, born on 18 July 1944.

Henrik Gürtler has been president and CEO of Novo A/S, Denmark, since
2000. He  was employed  by  Novo Industri  A/S,  Denmark, as  an  R&D
chemist in the Enzymes Division in  1977. After a number of years  in
various specialist  and managerial  positions  within this  area,  Mr
Gürtler was  appointed corporate  vice  president of  Human  Resource
Development in Novo Nordisk A/S in 1991, and in 1993 he was appointed
corporate vice  president  of Health  Care  Production. In  1996,  he
became a  member of  Corporate Management  of Novo  Nordisk A/S  with
special responsibility for Corporate Staffs.
Mr Gürtler is chairman of the boards of Novozymes A/S and  Copenhagen
Airports A/S, both Denmark. He is vice-chairman of the Board of  COWI
A/S, Denmark, and a member of  the Board of Brødrene Hartmanns  Fond,
Denmark.
Mr Gürtler  has an  MSc in  Chemical Engineering  from the  Technical
University of Denmark from 1976.
Mr Gürtler was elected to the Board  of Novo Nordisk A/S in 2005  and
re-elected in 2006 and  2007. His term as  a board member expires  in
March 2008.
Mr Gürtler is not regarded as an independent board member due to  his
former position as an executive in  Novo Nordisk A/S and his  present
position as president and CEO of Novo A/S.
The special competences  possessed by Mr  Gürtler that are  important
for the  performance of  his duties  are his  knowledge of  the  Novo
Group's  business  and  its  policies   and  his  knowledge  of   the
international biotech industry.
Mr Gürtler is a Danish national, born on 11 August 1953.

Kurt Anker Nielsen is a former CFO and deputy CEO of Novo Nordisk A/S
and a former CEO of Novo A/S. He serves as vice-chairman of the Board
of Novozymes A/S and  as a member  of the Board  of Directors of  the
Novo  Nordisk  Foundation,   LifeCycle  Pharma   A/S,  Denmark,   and
ZymoGenetics, Inc, US. He is chairman  of the Board of Reliance  A/S,
Denmark, and a member of the boards of StatoilHydro ASA, Norway,  and
Vestas  Wind  Systems   A/S,  Denmark.  In   LifeCycle  Pharma   A/S,
ZymoGenetics, Inc, StatoilHydro ASA and Vestas Wind Systems A/S he is
also the  elected  Audit Committee  chairman.  Mr Nielsen  serves  as
chairman  of  the  Board  of  Directors  of  Collstrup's  Mindelegat,
Denmark.
Mr Nielsen has an  MSc in Commerce  and Business Administration  from
the Copenhagen Business School, Denmark, from 1972.
Mr Nielsen was elected to the Board  of Novo Nordisk A/S in 2000  and
has been re-elected several times, most recently in 2007. His term as
a board member expires in March 2008.
Mr Nielsen is chairman of the Audit Committee at Novo Nordisk A/S and
is also designated as Audit Committee financial expert.
Mr Nielsen  qualifies as  an independent  Audit Committee  member  as
defined by the US Securities and Exchange Commission (SEC). He is not
regarded as an  independent board member  under the Danish  Corporate
Governance Recommendations (2005)  due to his  former position as  an
executive in Novo Nordisk A/S and his membership of the Board of  the
Novo Nordisk Foundation.
The special competences  possessed by Mr  Nielsen that are  important
for the performance of his duties are his in-depth knowledge of  Novo
Nordisk A/S and its businesses,  his working knowledge of the  global
pharmaceutical  industry   and  his   experience  in   working   with
accounting, financial and capital markets issues.
Mr Nielsen is a Danish national, born on 8 August 1945.

Jørgen Wedel was  executive vice president  of the Gillette  Company,
US,  until  2001.  He  was  responsible  for  Commercial  Operations,
International, and was  a member of  Gillette's Corporate  Management
Group. Since 2004, he has been a board member of ELOPAK AS, Norway.
Mr Wedel has an MSc in Commerce and Business Administration from  the
Copenhagen Business School, Denmark, from  1972, and an MBA from  the
University of Wisconsin, US, from 1974.
Mr Wedel was elected to the Board of Novo Nordisk A/S in 2000 and has
been re-elected several times, most recently  in 2007. His term as  a
board member expires in March 2008. Mr Wedel is a member of the Audit
Committee at Novo Nordisk A/S.
Mr Wedel  qualifies  as  an independent  Audit  Committee  member  as
defined by the  US Securities  and Exchange Commission  (SEC) and  is
regarded as an  independent board member  under the Danish  Corporate
Governance Recommendations (2005).
The special competences possessed by Mr Wedel that are important  for
the performance of his  duties are his background  as a senior  sales
and marketing  executive in  a globally  operating  consumer-oriented
company within the fast-moving consumer goods industry, as well as  a
particular insight into the US market.
Mr Wedel is a Danish national, born on 10 August 1948.

Pamela J Kirby is chairman  of the Board of  Scynexis Inc, US, and  a
board member  of  Smith  &  Nephew Plc,  UK,  Informa  Plc,  UK,  and
Curalogic A/S, Denmark. From  2001 to 2003, Dr  Kirby was CEO of  the
contract research organisation  Quintiles Transnational  Corporation,
US, and before that Dr Kirby was director Global Strategic  Marketing
in F. Hoffman-La Roche Limited, Switzerland, from 1998 to 2001.  From
1996 to 1998, Dr Kirby was commercial director in British Biotec Plc,UK, and  from  1979 to  1996  Dr Kirby  was  employed by  Astra  (now
AstraZeneca) in  various international  positions, most  recently  as
regional director/vice  president Corporate  Strategy, Marketing  and
Business Development.
Dr Kirby  has a  BSc in  Pharmacology (1975)  and a  PhD in  Clinical
Pharmacology (1978), both from the University of London, UK.
Dr Kirby is nominated for election to the Board of Directors of  Novo
Nordisk A/S at the Annual General Meeting in March 2008 for the first
time.
Dr Kirby is regarded as an independent board member.
Dr Kirby is a British national, born on 23 September 1953.

The Board  of Directors  recommends election  of Dr  Kirby  primarily
because of  her  scientific qualifications  and  extensive  executive
background  within  the  international  pharmaceutical  and   biotech
industry, particularly as relates  to marketing, strategic  planning,
clinical   trials   and   lifecycle   management   in   relation   to
pharmaceutical products.
                                                   *******
In the  Danish Corporate  Governance  Recommendations (2005),  it  is
recommended that at least  half of the board  members elected by  the
Annual General Meeting be independent of the Company.
Kurt Anker Nielsen  and Henrik Gürtler  were chief financial  officer
and corporate executive  vice president  with special  responsibility
for Corporate Staffs of Novo Nordisk A/S, respectively, prior to  the
demerger  into  Novo   Nordisk  A/S  and   Novozymes  A/S  in   2000.
Furthermore, Mr Nielsen,  Mr Gürtler  and Dr Ando  hold executive  or
board  positions  in  Novo  A/S  and  the  Novo  Nordisk  Foundation,
respectively. If the proposed candidates are elected to the Board  of
Directors, the Board  of Directors will  satisfy the requirements  of
the Danish  Corporate Governance  Recommendations (2005)  as four  of
seven of the board members elected by the Annual General Meeting  are
independent  of  the  Company  according  to  the  criteria  of   the
Recommendations. In addition, the  proposed composition of the  Board
of Directors will enable the Board  of Directors to elect members  to
the Audit  Committee  that qualify  as  independent as  required  and
defined by the US Securities and Exchange Commission (SEC).
The Board  of Directors  considers  that the  size  of the  Board  is
appropriate in relation to the requirements of the Company.
                                                   *******
Re agenda item 6 - Proposals of the Board of Directors:

Re agenda item 6.1:
The Board of Directors proposes a reduction of the Company's B  share
capital from DKK  539,472,800 to DKK  526,512,800 by cancellation  of
part of the Company's portfolio of own B shares at a nominal value of
DKK 12,960,000 divided into 12,960,000 B shares of DKK 1 each.  After
the implementation  of the  share  capital reduction,  the  Company's
share capital will amount  to DKK 634,000,000,  divided into A  share
capital of DKK 107,487,200 and B share capital of DKK 526,512,800.
Pursuant to the Danish Public Limited Companies Act, Section 44  (2),
cf Section 44 a (1), it is  stated that the purpose of the  reduction
of the  Company's  share  capital  is  to  distribute  funds  to  the
shareholders as  the reduction  amount has  been distributed  to  the
shareholders in  payment  of  shares  purchased  by  the  Company  in
accordance with the authorisations granted to the Board of  Directors
at previous  general meetings.  As  a result,  the share  capital  is
reduced by nominally  DKK 12,960,000 and  the Company's portfolio  of
treasury shares is  reduced by  12,960,000 B  shares of  DKK 1  each.
Pursuant to the  Danish Public  Limited Companies Act,  Section 44  a
(3), it is stated that these own B shares were acquired for the total
sum of DKK 3,208,636,800, which means that in addition to the nominal
amount of reduction,  DKK 3,195,676,800 has  been distributed to  the
shareholders.
The Board  of Directors'  proposal to  reduce the  Company's B  share
capital is made in order to maintain capital structure flexibility.
Adoption of the proposal implies the following change of Article  4.1
in the Articles of Association of  the Company that will take  effect
upon completion of the capital reduction:"4.1  The  share capital of  the Company amounts  to DKK  634,000,000
divided into A share capital of  DKK 107,487,200 and B share  capital
of DKK 526,512,800."

Re agenda item 6.2:
The Board  of  Directors proposes  that  the Annual  General  Meeting
authorises the  Board of  Directors, until  the next  Annual  General
Meeting, to allow the Company to acquire  own shares of up to 10%  of
the share capital and at the price quoted at the time of the purchase
with a deviation of  up to 10%,  cf Article 48  of the Danish  Public
Limited Companies  Act. Such  authorisation  is customary  in  Danish
listed companies.

Re agenda item 6.3:
The World Diabetes  Foundation (WDF) is  dedicated to supporting  the
prevention and treatment of diabetes in the developing world  through
the funding of sustainable projects. At its core lies the promise  of
equal access  to  diabetes care.  The  WDF was  established  by  Novo
Nordisk A/S in  2002 through  a commitment  to donate  an amount  not
exceeding DKK  65  million  per  year  until  2010.  The  WDF  is  an
independent trust and is  governed by a board  of six experts in  the
fields of  diabetes, access  to  health and  development  assistance.
Since 2002, the WDF has successfully funded 138 projects in more than
70 developing countries, and it is estimated that these projects will
potentially influence  the diabetes  treatment of  55 million  people
directly.

The Board of Directors of Novo Nordisk A/S wishes to secure that  the
WDF is able to continue its  activities after expiry of the  original
donation in  2010  and proposes    that the  Annual  General  Meeting
approves a donation by Novo Nordisk to  the WDF of an amount up to  a
total  of  DKK  575  million  to  be  granted  as  individual  annual
contributions over a period  of 10 years as  from the financial  year
2008 through to  the financial  year 2017.  The annual  contributions
will be  calculated based  on the  Novo Nordisk  Group's net  insulin
turnover in the relevant financial year.

The proposal  will  supplement the  remaining  part of  the  existing
donation programme  in 2008  through to  2010 and  at the  same  time
extend Novo Nordisk's donation period through to 2017. The  following
shall apply to the new WDF donation:
-   For 2008, 2009 and 2010: The annual contribution amounts to 0.01%
of the  Novo Nordisk  Group's net  insulin turnover  in the  relevant
year, provided that the contribution cannot exceed DKK 5 million  per
year. The contributions  are in addition  to contributions under  the
existing donation  adopted in  2002  of 0.25%  per  year of  the  net
insulin turnover in the relevant year subject to a maximum of DKK  65
million per year. The  combined maximum donation  per year under  the
two donation programmes is DKK 70 million.
-    For 2011  through to 2017:  The annual  contribution amounts  to
0.125% of  the  Novo Nordisk  Group's  net insulin  turnover  in  the
relevant year, provided  that the contribution  cannot exceed DKK  80
million per year.
The proposed donation  cannot for any  given year exceed  15% of  the
taxable income of Novo Nordisk A/S in such year.

Re agenda item 6.4:
Novo Nordisk's existing overall remuneration policy aims to  attract,
retain and motivate members of  the Board of Directors and  Executive
Management of Novo Nordisk A/S.  Remuneration levels are designed  to
be competitive and to  align the interests of  the board members  and
executives with  those  of the  shareholders.  A description  of  the
overall remuneration policy of Novo Nordisk  A/S can be found in  the
Annual Report pp 44-45 and  at the Company's website  novonordisk.com
under 'About Novo Nordisk' -  'Corporate governance'.

Guidelines for incentive-based remuneration form part of the  overall
remuneration policy. In light of recently enacted Danish legislation,
Novo Nordisk A/S presents for approval at the Annual General  Meeting
in 2008 its guidelines for incentive-based remuneration for the Board
of Directors  and  Executive  Management of  Novo  Nordisk  A/S.  The
guidelines, which  are  attached  as  Appendix  1,  comply  with  the
recently enacted  legislation,  which requires  listed  companies  to
prepare and obtain general meeting  approval of such guidelines as  a
precondition for granting incentive-based remuneration to  management
and board members.

The guidelines  for  incentive-based  remuneration  as  well  as  the
overall remuneration policy of Novo Nordisk A/S are available at  the
Company's website novonordisk.com.

Upon approval of the  guidelines by the  Annual General Meeting,  the
following new  Article  14  will  be  inserted  in  the  Articles  of
Association:"14   Guidelines for incentive-based remuneration

14.1  The  Company  has  laid  down  guidelines  for  incentive-based
remuneration for the Board of Directors and Executive Management. The
guidelines, which have been adopted by the Company's general meeting,
are available at the Company's website: novonordisk.com."

The current Articles 14 through  17 will be re-numbered  accordingly.
Further, the references  in Article  5.3 are updated  to reflect  the
revised numbering.

Ad agenda item 6.5 - Amendments to the Articles of Association:

Agenda item 6.5.1:
Amendment of  Article  4.2  and Articles  9.2-9.3:  Novo  Nordisk  in
December  2007  completed  a  stock  split  by  changing  the   share
denomination from  DKK 2.00  to DKK  1.00, the  minimum  denomination
permitted under the  current Articles  of Association.  To allow  the
Board of  Directors  to  implement additional  stock  splits  in  the
future, the Board of  Directors proposes a  reduction of the  minimum
denomination (nominal value) of shares stipulated by the Articles  of
Association from DKK 1.00 to DKK 0.01.

As a consequence of the proposed amendment the voting power  attached
to the Company's  shares will be  amended to the  effect that each  B
share capital amount of DKK  0.01 (the minimum nominal  denomination)
shall carry one vote and each A share capital amount of DKK 0.01 (the
minimum nominal denomination) shall carry 10 votes. The change  means
that each  B share  of DKK  1.00 (the  present denomination  of  Novo
Nordisk's shares) will carry 100 votes  and each A share of DKK  1.00
will carry 1,000 votes. The voting  ratio between the A and B  shares
is thus not affected by the change.

The proposed amendment means that future changes of the  denomination
of the Company's shares may be implemented by the Board of  Directors
subject to the limit stipulated by the Articles of Association.  Such
potential future changes will not affect the voting ratio between the
A and B shares.

Agenda item 6.5.2:
Amendment of Article 6.3:  The Board of  Directors proposes that  the
authorisation of  the  Board  of  Directors in  Article  6.3  of  the
Articles of  Association  to  issue B  shares  to  employees  without
pre-emptive subscription rights for existing shareholders be extended
until 12 March 2013 and that  it be reduced from the current  maximum
nominal amount of approximately DKK  21 million to a maximum  nominal
amount of DKK 4  million. The Board of  Directors considers that  the
reduced  size  of  the  authorisation  is  in  accordance  with  good
corporate governance practices and also reflective of the  reductions
in the share capital effected by the Company in recent years.

Agenda item 6.5.3:
Amendment of Articles 6.4-6.6: The  Board of Directors proposes  that
the existing authorisations  of the  Board of  Directors in  Articles
6.4-6.6 of the Articles of Association to increase the share  capital
be replaced by an  authorisation of the Board  of Directors until  12
March 2013 to increase the share capital by a nominal amount up to  a
maximum of DKK  126 million through  one or more  separate issues  of
shares.

New shares  paid in  cash may  be A  shares, B  shares or  both.  The
shareholders will  have pre-emptive  subscription rights  to any  new
shares in accordance with the Articles of Association and the  Danish
Public Limited Companies  Act. The Board  of Directors may,  however,
decide to issue B shares without pre-emptive subscription rights  for
the shareholders if the shares are paid in cash and the  subscription
price equals the market price. The Board of Directors may also decide
to issue new shares to  be paid in assets  other than cash, in  which
case such new shares shall be B shares, which will be issued  without
pre-emptive subscription rights for existing shareholders.

Compared to the existing authorisations  under Articles 6.4 and  6.5,
the amount  of shares  which may  be issued  under the  new  proposed
authorisation is reduced to nominally DKK 126 million compared to the
existing total of nominally DKK  200 million. The Board of  Directors
considers that the reduction implicit  in this proposal of the  total
amount  of  new  shares  which  may  be  issued  without  pre-emptive
subscription rights is in  accordance with good corporate  governance
practices.

Agenda item 6.5.4:
Amendment of Article  7.2: A  recent reform of  the Danish  municipal
sector has introduced  new municipality  names and  regions, and  the
Board of Directors consequently proposes that Article 7.2 be  amended
to reflect that  the future  General Meetings  shall be  held in  the
Capital Region of Denmark.

Agenda item 6.5.5:
Amendment  of  Article  7.4:  The  Board  of  Directors  proposes  an
amendment of  Article  7.4 of  the  Articles of  Association  of  the
Company,  whereby  the  number  of  shares  required  to  request  an
Extraordinary General  Meeting  is reduced  from  1/10 of  the  share
capital (the maximum permitted by the Danish Public Limited Companies
Act) to 1/20 of the share capital.

The  proposal  is  intended  to  enhance  the  corporate   governance
practices of the Company and to improve the shareholders' ability  to
exercise their influence.
                                                   ********
To adopt the proposal to reduce  the share capital under agenda  item
6.1 and to adopt each of the proposals for amendment of the  Articles
of Association under agenda items  6.5.1 through 6.5.5, at least  two
thirds of the total number of  votes in the Company shall be  present
at the Annual General  Meeting and at least  two thirds of the  votes
cast as  well as  of  the share  capital  represented at  the  Annual
General Meeting shall vote  for the proposals,  cf Articles 10.2  and
10.3 of the Articles of Association. The proposals under agenda  item
6.2 through to 6.4 may be adopted by a simple majority of votes cast.
                                                   ********
The current share capital of  the Company amounts to DKK  646,960,000
divided into A share capital of  DKK 107,487,200 and B share  capital
of DKK 539,472,800. The  A shares have  10 votes per DKK  1 of the  A
share capital, whereas the B shares have one vote per DKK 1 of the  B
share capital. A shareholder is entitled  to attend and to vote at  a
General Meeting provided  the shareholder has  obtained an  admission
card  (see  below).  The  voting   rights  may  be  exercised  by   a
proxy-holder provided  such  holder substantiates  his/her  right  to
attend the General Meeting by presenting an admission card and a duly
dated written instrument of proxy.
                                                   ********
The Board of Directors invites all shareholders to attend the  Annual
General Meeting. Please note that the Annual General Meeting is  held
at  Radisson   SAS,  Falkoner   Centret,   Falkoner  Allé   9,   2000
Frederiksberg. Admission  and voting  cards  for the  Annual  General
Meeting may be obtained by  returning the enclosed requisition,  duly
completed and  signed, to  VP  Investor Services  A/S ("VP")  in  the
enclosed envelope so that VP  receives the requisition no later  than
Friday 7 March  2008 at  4 pm. Alternatively,  you may  phone VP,  no
later than  Friday  7 March  2008  at 4  pm  on tel  +45  4358  8866.
Admission cards can also be ordered on VP's website  www.uk.vp.dk/agm
no later than Friday 7 March 2008 at 4 pm.

Registered shareholders will be able to request admission and  voting
cards and to submit voting instructions by power of attorney via  the
Company's   website   novonordisk.com/AGM   or   via   VP's   website
www.uk.vp.dk/agm using a compatible electronic signature.  Electronic
signatures  used   for  net-banking   services  offered   by   credit
institutions based  in  Denmark  will typically  be  compatible.  For
further information  please  see novonordisk.com/AGM.  Submission  of
requests for  admission and  voting cards  and submission  of  voting
instructions via the  Company's website  or VP's  website shall  take
place no later than Friday 7 March 2008 at 4 pm.

At this year's Annual General Meeting representatives of the  Company
and the chairman  of the  Annual General Meeting  will conduct  their
presentations in English. Shareholders will  be entitled to speak  in
Danish or English.  Simultaneous translation from  English to  Danish
and from  Danish  to  English will  be  available  for  participating
shareholders. The resolutions of the meeting will be recorded in  the
minutes which according to Danish  company law shall apply Danish  as
the formal language. An  English translation of  the minutes will  be
made available.

Again this year, the Company will webcast the Annual General  Meeting
live in a  Danish and an  English version. Please  see the  Company's
website novonordisk.com.

Prior to the Annual General Meeting the requested admission card will
be sent to you  at the address entered  in the Company's register  of
shareholders. The admission card  will show the  number of votes  you
are entitled to according to  the register of shareholders,  pursuant
to Article 9 of the Articles  of Association. If you have not  stated
an address to which the admission  card shall be sent, the  admission
card must be collected at the Company's office no later than the  day
before the Annual General Meeting.

The agenda for the Annual General Meeting together with the  complete
proposals and the  audited Annual  Report 2007 will  be available  to
shareholders for  inspection  at  the Company's  office,  Novo  Allé,
DK-2880 Bagsværd, on weekdays between 10  am and 2 pm from  Wednesday
20 February 2008  to Wednesday 12  March 2008. As  from Wednesday  20
February, the documents will also be available for inspection at  the
Company's  website  novonordisk.com  under  'About  Novo  Nordisk'  -
'Corporate governance' or  you can  order a copy  by contacting  Novo
Nordisk A/S on tel +45 4442 3434.
If you are not able to  attend the Annual General Meeting, the  Board
of Directors  would  appreciate receiving  a  proxy to  exercise  the
voting rights  attached  to  your  shares. If  you  consent  to  this
procedure, you are kindly  asked to return  the attached proxy  form,
signed and dated,  so that  it is in  VP's possession  no later  than
Friday 7 March  2008 at  4 pm.  Alternatively, within  the same  time
limit voting instruction may be  submitted via the Company's  website
or via VP's website  as described above. According  to Danish law,  a
proxy for  the Annual  General Meeting  is  only valid  if it  is  in
writing (or submitted  via qualified  IT systems) and  is signed  and
dated after 12  March 2007 (ie,  one year before  the Annual  General
Meeting in 2008, at the earliest).
After  deduction  of  potential  withholding  tax,  the  dividend  as
approved at the Annual  General Meeting will  be transferred to  Novo
Nordisk  A/S'  shareholders  via  VP  Securities  Services.   Further
information on dividend can be found in the Annual Report 2007 p 50.
You  can  reach   Radisson  SAS,   Falconer  Centret   by  Metro   to
Frederiksberg Station. Leave Frederiksberg Metro Station through  the
Falkoner Allé exit.  Make a right-hand  turn and walk  100 metres  up
Falkoner Allé,  and Falkoner  Centret is  located on  the  right-hand
side. You can also reach Falconer Centret with Movia buses (lines 14,
15 and 18  stop at  Frederiksberg town  hall, a  short distance  from
Falconer Centret). Car parking  facilities are available at  Falkoner
Centret for a  minor fee. Attendees  arriving by car  are advised  to
arrive well in advance of the meeting as it may be difficult to  find
parking at or near Falkoner Centret.
Novo Nordisk will host an information meeting conducted in Danish for
the Company's  shareholders on  Thursday 13  March 2008  at 5  pm  at
Radisson SAS, Falkoner Centret. Further information about the meeting
may be obtained at the Company's website novonordisk.com/AGM.
Yours sincerely
Novo Nordisk A/S
The Board of Directors
Appendix 1
Guidelines for incentive-based remuneration for the Board of
Directors and Executive Management of Novo Nordisk A/S

These Incentive Guidelines apply to incentive programmes for the
Board of Directors and Executive Management in Novo Nordisk A/S,
where remuneration is dependent on individual or company performance.

The Board of Directors
The members of the Board of Directors are remunerated with a fixed
fee and are not offered stock options, warrants or participation in
other incentive programmes where remuneration is dependent on
individual or company performance.

Executive Management
Executive Management (meaning the executives registered as executives
with the Danish Commerce and Companies Agency) may be entitled to
participate in the following incentive programmes: 1) a Short-term
Incentive Programme and 2) a Long-term Incentive Programme.
The short-term incentive programme may result in a maximum payout per
year equal to four months' fixed base salary plus pension
contribution. The long-term incentive programme may result in a
maximum grant per year equal to eight months' fixed base salary plus
pension contribution. Consequently, the aggregate maximum amount that
may be granted as incentives for a given year is equal to 12 months'
fixed base salary plus pension contribution for each member of
Executive Management.
Apart from the above-mentioned programmes, members of Executive
Management are not offered stock options, warrants or participation
in other incentive programmes where remuneration is dependent on
individual or company performance.

Short-term Incentive Programme (STIP)
The STIP consists of a cash bonus which is linked to the achievement
of a number of pre-defined functional and individual business targets
for each member of Executive Management. The targets for the chief
executive officer are fixed by the chairman of the Board of Directors
while the targets for the executive vice presidents are fixed by the
chief executive officer. The chairman of the Board evaluates the
degree of target achievement for each member of the Executive
Management, and cash bonuses for a particular financial year - if any
- are paid at the beginning of the subsequent financial year.
The cash bonus for each participating member cannot exceed an amount
equal to four months' fixed base salary plus pension contribution per
year. The calculation of the cash bonus - if any - for a year is
typically based on the salary in December.

Long-term Incentive Programme (LTIP)
Each year in January the Board of Directors decides whether or not to
establish an LTIP for that calendar year.
The LTIP is based on an annual calculation of shareholder value
creation as compared to the budgeted performance for the year.
In line with Novo Nordisk's long-term financial targets, the
calculation of shareholder value creation is based on reported
operating profit after tax reduced by a Weighted Average Cost of
Capital (WACC)-based return requirement on average invested capital.
A proportion of the calculated shareholder value creation is
allocated to a joint pool for participants, which in addition to
Executive Management includes the other members of the Senior
Management Board (i.e. the Senior Vice President's of the Novo
Nordisk Group).
For members of Executive Management the joint pool operates with a
yearly maximum allocation per participant equal to eight months'
fixed base salary plus pension contribution.
The joint pool may, subject to the Board of Directors' assessment, be
reduced in case of a lower than planned performance on significant
research and development projects and key sustainability projects.
Targets for non-financial performance related to sustainability and
research and development projects may include achievement of certain
milestones within set dates.
Once the joint pool has been approved by the Board of Directors the
total cash amount is converted into Novo Nordisk A/S B shares at
market price. The market price is calculated as the average trading
price for Novo Nordisk A/S B shares on the OMX Nordic Exchange
Copenhagen in the open trading window following the release of
financial results for the year prior to the bonus year; i.e. in the
open trading window following immediately after the Board of
Directors approval of the programme.
The shares in the joint pool are allocated to the participants on a
pro rata basis: the chief executive officer participates with three
units, executive vice presidents participate with two units each and
the other members of the Senior Management Board participate with one
unit each.
The shares in the joint pool for a given year will be locked up for
three years before it is transferred to the participants, including
Executive Management. Upon resignation during the lock-up period by a
participant, the shares will remain in the joint pool to the benefit
of the other participants.
In the lock-up period the Board of Directors may remove shares from
the joint pool in case of lower than planned value creation in
subsequent years, eg if the economic profit falls below a predefined
threshold compared to the budget for a particular year.
In the lock-up period the market value of the joint pool will change
dependent upon the development in the Novo Nordisk B share price and
consequently the interests of the participants including Executive
Management are aligned with those of the shareholders.
No dividends are paid on shares in the bonus pool in the lock-up
period and the shares in the bonus pool are administered as part of
Novo Nordisk's holding of treasury shares.
Novo Nordisk continuously covers its obligations under the LTIP
through its holding of treasury shares.
In the examples below - that have been included for illustrative
purposes only - it is assumed that the maximum number of shares -
corresponding to eight months' worth of fixed base salary is
allocated to the bonus pool. It is further assumed that the number of
shares in the bonus pool is not reduced during the lock-up period.

Example 1: If the share price increases by 10% per annum and the
fixed base salary increases by 4% per annum in the lock-up period,
the value of the shares at payout will correspond to approximately 10
months' fixed base salary in the year of payout.

Example 2: If the share price stays flat and the fixed base salary
increases by 4% per annum in the lock-up period, the value of the
shares at payout will correspond to approximately seven months' fixed
base salary in the year of payout.


Table showing remuneration for members of the Board of Directors and
Executive Management:


+-------------------------------------------------------------------+
|                      | Board of        | Executive Management     |
|                      | Directors       |                          |
|----------------------+-----------------+--------------------------|
| Fixed base salary    | Yes             | Yes                      |
|----------------------+-----------------+--------------------------|
| Fee for Committee    | Yes             | No                       |
| work                 |                 |                          |
|----------------------+-----------------+--------------------------|
| Fee for ad hoc tasks | Yes             | No                       |
|----------------------+-----------------+--------------------------|
| STIP                 | No              | Up to four months' fixed |
| (Short Term          |                 | base salary plus pension |
| Incentive            |                 | contribution per year    |
| Programme)           |                 |                          |
|----------------------+-----------------+--------------------------|
| LTIP                 | No              | Up to eight months'      |
| (Long Term Incentive |                 | fixed                    |
| Programme)           |                 | base salary plus pension |
|                      |                 | contribution per year    |
|----------------------+-----------------+--------------------------|
| Pension              | No              | 25-30% of fixed base     |
|                      |                 | salary and bonus         |
|----------------------+-----------------+--------------------------|
| Non-monetary         | No              | Negotiated individually  |
| benefits             |                 |                          |
|----------------------+-----------------+--------------------------|
| Severance payment    | No              | Based on tenure of       |
|                      |                 | employment,12-36         |
|                      |                 | months' fixed base       |
|                      |                 | salary                   |
|                      |                 | plus pension             |
|                      |                 | contribution             |
+-------------------------------------------------------------------+
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