Protherics PLC announces Annual Information Update


Cheshire, UK--(Marketwire - July 25, 2008) -


Protherics PLC


Annual Information Update


London, UK; Brentwood, TN, US: 25 July 2008 - In accordance with
Prospectus Rule 5.2, Protherics PLC ("Protherics" or the "Company"),
the international biopharmaceutical company focused on critical care
and cancer, sets out below a list of the information that has been
published or made available to the public during the period
beginning 20 July 2007 up to and including 24 July 2008.


In accordance with Article 27.3 of the Prospectus Directive Regulation,
we confirm that the information referred to in this Annual Information
Update was up to date at the time it was published but it is
acknowledged that such disclosures may now be or may at any time become
out of date due to changing circumstances.


1.    Announcements made via a Regulatory Information Service


The following UK regulatory announcements have been made via a
Regulatory Information Service. A copy of

these announcements can be obtained from the London Stock Exchange

website, www.londonstockexchange.com/marketnews or from the Company's
website www.protherics.com



Date          Brief Description of Announcement

22 July 2008  Annual General Meeting Results

22 July 2008  AGM and Interim Management statement

10 July 2008  Director/PDMR Shareholding

4 July 2008   Interest in Shares

4 July 2008   Issue of Shares

2 July 2008   Total Voting Rights

24 June 2008  Documents lodged with the UK Listing Authority's Document
              Viewing Facility

24 June 2008  Research Update

13 June 2008  Holding(s) in Company

13 June 2008  Notification of Directors' Interests

10 June 2008  Notification of Directors'/PDMRs' Interests

3 June 2008   Notification of Directors'/PDMRs' Interests

3 June 2008   Preliminary Results for the year ended 31 March 2008

2 June 2008   Research Update

15 May 2008   Notice of Results

1 May 2008    Total Voting Rights

22 April 2008 Research Update

10 April 2008 Block Listing Returns

1 April 2008  Total Voting Rights

6 March 2008  Application for Block Listing

4 March 2008  Total Voting Rights

26 February   Holding(s) in Company
2008

14 February   Interim Management Statement
2008

8 February    Blocklisting Interim Review
2008

24 January    Research Update
2008

22 January    Holding(s) in Company
2008

22 January    Research Update
2008

11 January    Research Update
2008

20 December   Holding(s) in Company
2007

3 December    Total Voting Rights
2007

29 November   Application for Listing
2007

26 November   Notification of Directors' Interests
2007

26 November   Notification of PDMR Interests
2007

23 November   Major Interest in Shares
2007

20 November   Research Update
2007

20 November   Interim Results for six months ended 30 September 2007
2007

19 November   Holding(s) in Company
2007

9 November    Notice of Interim Results
2007

2 November    Issue of Loan Notes
2007

31 October    Total Voting Rights
2007

30 October    Holding(s) in Company
2007

23 October    Holding(s) in Company
2007

8 October     Block Listing Returns
2007

1 October     Director's Dealings
2007

28 September  Total Voting Rights
2007

26 September  Licensing Agreement
2007

25 September  Holding(s) in Company
2007

25 September  Licensing Agreement
2007

21 August     Holding(s) in Company
2007

16 August     Holding(s) in Company
2007

13 August     Notification of Directors'/PDMRs' Interests
2007

10 August     Board Changes
2007

9 August 2007 Blocklisting Interim Review

31 July 2007  Total Voting Rights

26 July 2007  Holding(s) in Company

26 July 2007  AGM Results

26 July 2007  AGM and Interim Management Statement

20 July 2007  Annual Information Update



2.    Documents filed at Companies House


The Company has also made the following filings with Companies House on
or around the dates indicated.  Copies of these documents can be
obtained from Companies House at Crown Way, Maindy, Cardiff CF14 3UZ
(Telephone +44 (0) 870 3333 636,
email: enquiries@companies-house.gov.uk) or from Companies House
website www.companieshouse.gov.uk


Date           Document Filed

18 July 2008   88(2)R - Allotment of Shares

15 July 2008   88(2)R - Allotment of Shares

26 June 2008   88(2)R - Allotment of Shares

7 May 2008     88(2)R - Allotment of Shares

21 February    288c - Change in Director's Particulars
2008

18 February    88(2)R - Allotment of Shares
2008

13 February    363s - Return made up to 12/01/2008; Bulk list available
2008           separately

13 December    88(2)R - Allotment of Shares
2007

22 October     88(2)R - Allotment of Shares
2007

25 September   88(2)R - Allotment of Shares
2007

21 August 2007 Increases in nominal share capital and copy of Special
               Resolutions

21 August 2007 288a - Appointment of Director

21 August 2007 288b - Resignation of Director

10 August 2007 Special Resolutions passed at 2007 AGM

25 July 2007   Full Accounts made up to 31 March 2007



3.    Documents published


The following documents were published by the Company on or around the
dates indicated:


Date         Document Description

24 June 2008 Annual Report and Financial statements for year ending 31
             March 2008 and Circular to Shareholders containing Notice
             of 2008 Annual General Meeting

20 November  Interim Report for the 6 months to 30 September 2007.
2007



Copies of the Company's Annual Report and Financial
Statements and Interim Report are available from the Company's website 
www.protherics.com. Alternatively, the above documents can be
obtained through the Company Secretary at the Company's registered
office, the Heath Business and Technical Park, Runcorn, Cheshire WA7
4QX.  


/ Ends /



For further information please contact:


Protherics 

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600



Or visit  www.protherics.com


                    This information is provided by RNS
          The company news service from the London Stock Exchange

END

Contact Information: Contacts: RNS Customer Services 0044-207797-4400 http://www.rns.com

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