CHESHIRE, UK--(Marketwire - August 8, 2008) -

Protherics PLC

Block Listing Six Monthly Return

6% Unsecured Convertible Loan Notes

London, UK; Brentwood, TN, US: 8 August 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, in accordance with Listing
Rule 3.5.6, notifies the following details in respect of a block
listing for the Company's 6% Unsecured Convertible Loan Notes:  

Name of applicant:                  Protherics PLC

Name of scheme:                     Block Listing in respect
                                    of 6% Unsecured Convertible Loan

Period of return:          From:    9 February 2008  To: 8 August 2008

Balance of unallotted               8,430,060 Ordinary Shares (Loan
securities under scheme from        Notes to the value of GBP2,107,515)
previous return:

The amount by which the block        Nil
scheme has been increased since the
date of the last return:

Number of securities issued/           
allotted under scheme during
period:                             292,388 Ordinary Shares (Loan Notes
                                    to the value of GBP73,097)

Balance under scheme not yet issued  
/allotted at end of period
                                    8,137,672 Ordinary Shares (Loan
                                    Notes to the value of GBP2,034,418)

Number                              17,092,476 Ordinary Shares (Loan
and class of securities originally  Notes to the value of GBP4,273,119)
listed and the date of admission    admitted on 8 February 2005

Total number of securities in issue 342,159,034 Ordinary Shares
at the end of the period

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600

Or visit

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