Protherics PLC Notification of Major Interests in Shares London, UK; Brentwood, TN, US: 14 August 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that on 13 August 2008, in accordance with the Transparency Obligations Directive, a notification of interest in the ordinary share capital of the Company was received from AXA Investment Managers UK Limited on behalf of AXA S.A. and its Group Companies ("AXA"). The notification follows an increase in its Indirect Voting Rights. Details of the interest notified are as follows: 1. Reason for the notification (please tick the appropriate box or boxes) A acquisition of voting rights X An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached An event changing the breakdown of voting rights Other (please specify): 2. Full name of person(s) subject to the AXA S.A., 25 Avenue notification obligation: Matignon, 75008 Paris and its group of companies. 3. Full name of shareholder(s) (if different from 2.): 4. Date of the transaction (and date on which 12 August 2008 the threshold is crossed or reached if different): 5. Date on which issuer notified: 13 August 2008 6. Threshold(s) that is/are crossed or 12% reached: 7. Notified details: A: Voting rights attached to shares Class/ Situation previous Resulting situation after type of to the Triggering the trigger transaction shares transaction if possible using Number Number of Number Number of voting the ISIN of Shares Voting of rights CODE Rights Shares Direct Direct Indirect Direct 0702920 41,926,236 41,926,236 941,666 941,666 41,084,570 0.28% % of voting rights Indirect 12.01% B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Exercise/ Number of voting rights that % of financial date Conversion may be acquired if the voting instrument Period/ instrument is exercised/ rights Date converted. Total (A+B) Number of voting rights % of voting rights 42,026,236 12.28% 8. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable : Name of Company/Fund Number of % of issued Shares share capital AXA UK Investment Co ICVC 511,882 0.14960 UK Smaller Companies Fund Indirect Sun Life Pensions Management Ltd 225,000 0.06576 Direct Sun Life Unit Assurance Ltd 53,913 0.01576 FTSE All Share Tracker Direct Sun Life Pensions Management 294,874 0.08618 FTSE All Share Tracker Direct AXA Framlington 425,000 0.12421 Indirect AXA Framlington 1,851,468 0.54111 Indirect AXA Framlington 1,909,918 0.55820 Indirect AXA Framlington 459,865 0.13440 Indirect AXA Framlington 639,353 0.18686 Indirect AXA Framlington 15,438,453 4.51207 Indirect AXA Framlington 13,753,131 4.01951 Indirect AXA Framlington 2,000,000 0.58452 Indirect AXA Framlington 1,500,000 0.43839 Indirect AXA Framlington 500,000 0.14613 Indirect AXA Framlington 220,000 0.06430 Indirect Framlington onshore private clients 975,500 0.28510 Indirect AXA Sun Life With Profits Passive 226,817 0.06629 Direct AXA Sun Life With Profits Passive 141,062 0.04123 Direct AXA Framlington 900,000 0.26304 Indirect Total Direct 941,666 0.27521 Total Indirect 41,084,570 12.00745 TOTAL 42,026,236 12.28266 Proxy Voting: 9. Name of the proxy holder: 10. Number of voting rights proxy holder will cease to hold: 11. Date on which proxy holder will cease to hold voting rights: 12. Additional information: / Ends / For further information please contact: Protherics Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510 Julie Vickers, Company Secretary +44 (0)1928 518010 Financial Dynamics - press enquiries London: Ben Atwell, Lara Mott +44 (0) 20 7831 3113 New York: John Capodanno +1 212 850 5600 Or visit www.protherics.com This information is provided by RNS The company news service from the London Stock Exchange END
Contact Information: Contacts: RNS Customer Services 0044-207797-4400 http://www.rns.com