CHESHIRE, UK--(Marketwire - August 14, 2008) -

Protherics PLC

Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 14 August 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that on 13
August 2008, in accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from AXA Investment Managers UK Limited on
behalf of AXA S.A. and its Group Companies ("AXA").  The notification
follows an increase in its Indirect Voting Rights.  Details of
the interest notified are as follows:

1.    Reason for the notification (please tick
the appropriate box or boxes)    

A acquisition of voting rights                   X

An acquisition or disposal of financial
instruments which may result in the acquisition
of shares already issued to which voting rights
are attached

An event changing the breakdown of voting rights

Other (please specify):

2. Full name of person(s) subject to the      AXA S.A., 25 Avenue
notification obligation:                      Matignon, 75008 Paris and
                                              its group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which 12 August 2008
the threshold is crossed or reached if

5. Date on which issuer notified:             13 August 2008

6. Threshold(s) that is/are crossed or        12%

7. Notified details:

A: Voting rights attached to shares

Class/      Situation previous       Resulting situation after  
type of     to the Triggering        the trigger transaction
shares      transaction                           
if possible
using       Number      Number of    Number   Number of voting  
the ISIN    of Shares   Voting       of       rights     
CODE                    Rights       Shares  
                                     Direct   Direct  Indirect   Direct 

0702920     41,926,236  41,926,236   941,666  941,666 41,084,570 0.28%

                                                          % of voting  


B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 

Total (A+B)

Number of voting rights     % of voting rights

42,026,236                  12.28%

8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund                          Number of   % of issued
                                              Shares      share capital

AXA UK Investment Co ICVC                     511,882     0.14960   

UK Smaller Companies Fund


Sun Life Pensions Management Ltd              225,000     0.06576


Sun Life Unit Assurance Ltd                   53,913      0.01576

FTSE All Share Tracker


Sun Life Pensions Management                  294,874     0.08618

FTSE All Share Tracker


AXA Framlington                               425,000     0.12421


AXA Framlington                               1,851,468   0.54111


AXA Framlington                               1,909,918   0.55820


AXA Framlington                               459,865     0.13440


AXA Framlington                               639,353     0.18686


AXA Framlington                               15,438,453  4.51207


AXA Framlington                               13,753,131  4.01951


AXA Framlington                               2,000,000   0.58452


AXA Framlington                               1,500,000   0.43839


AXA Framlington                               500,000     0.14613


AXA Framlington                               220,000     0.06430


Framlington onshore private clients           975,500     0.28510


AXA Sun Life With Profits Passive             226,817     0.06629


AXA Sun Life With Profits Passive             141,062     0.04123


AXA Framlington                               900,000     0.26304


Total Direct                                  941,666     0.27521

Total Indirect                                41,084,570  12.00745

TOTAL                                         42,026,236  12.28266

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting rights:

12. Additional information:

                              / Ends /

For further information please contact:

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  
Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 
New York: John Capodanno                    +1 212 850 5600

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