Protherics PLC - Holding(s) in Company


Cheshire, UK--(Marketwire - August 29, 2008) -


Protherics PLC


Notification of Major Interests in Shares



London, UK; Brentwood, TN, US: 29 August 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that today, in
accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from Invesco Perpetual on behalf of Invesco
Limited. Details of the interest notified are as follows:



1.    Reason for the notification (please tick the appropriate box
or boxes)    



An disposal of voting rights                                        Yes

An acquisition or disposal of financial instruments which may
result in the acquisition of shares already issued to which voting
rights are attached


An event changing the breakdown of voting rightsOther (please specify):

2. Full name of person(s) subject to the       Invesco Limited
notification obligation:

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which  28 August 2008
the threshold is crossed or reached if
different):

5. Date on which issuer notified:              29 August 2008

6. Threshold(s) that is/are crossed or         crossed 11% threshold to
reached:                                       10%

7. Notified details:



A: Voting rights attached to shares

Class/type of  Situation previous to Resulting situation after the trigg
ering
shares         the Triggering        transaction
               transaction 
if possible
using the ISIN Number of  Number of  Number of  Number of voting  % of v
oting
CODE           Shares     Voting     shares     rights            rights
                          Rights 
                                                Direct Indirect   Direct
 Indirect
               37,361,912 37,361,912 36,519,411        36,519,411       
 10.67%
Ordinary 2P
Shares

(GB0007029209)




B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 




Total (A+B)

Number of voting rights % of voting rights


36,519,411              10.67%



8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :


JP Morgan Chase - 6,604,464

Citibank - 29,918,947  




Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will cease to hold:

11. Date on which proxy holder will cease to hold voting    rights:



12. Additional information:




/ Ends /


For further information please contact:


Protherics 

Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010


Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600



Or visit  www.protherics.com

                    This information is provided by RNS
          The company news service from the London Stock Exchange

END

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