Cheshire, UK--(Marketwire - September 9, 2008) -

Protherics PLC

6 monthly Block Listing Return

London, UK; Brentwood, TN; 9 September 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, in accordance with Listing
Rule 3.5.6, notifies the following details in respect of the block
listing for its Long Term Incentive Plan and Deferred Bonus Plan:

Name of applicant:               Protherics PLC

Name of schemes:                 Protherics PLC Long Term Incentive
                                 Plan (LTIP), and Protherics
                                 PLC Deferred Bonus Plan (DBP)

Period of return:        From:   7 March 2008   To: 8 September 2008

Balance of unallotted            LTIP - 149,209 Ordinary Shares 
securities under schemes at
beginning of period:             DBP - 109,806 Ordinary Shares

The amount by which the block    Nil
schemes have been increased
during the period:

Number of securities issued/     LTIP - 44,900
allotted under schemes during
period:                          DBP - 36,818

Balance under schemes not yet    LTIP - 104,309
issued/allotted at end of period
                                 DBP - 72,988

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600

Or visit

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