Cheshire, UK--(Marketwire - October 9, 2008) -

Protherics PLC

6 monthly Block Listing Return

Individual Unapproved Share Options

London, UK; Brentwood, TN; 9 October 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, in accordance with Listing
Rule 3.5.6, notifies the following details in respect of the block
listing for its Individual Unapproved share option arrangements:

Name of applicant:                         Protherics PLC

Name of scheme:                            Individual Unapproved share
                                           option arrangements

Period of return:                From:     9 April    To:  8
                                           2008           October 2008

Balance of unallotted securities under     640,000
scheme at beginning of period:

The amount by which the block scheme has   Nil
been increased during the period:

Number of securities issued/allotted under Nil
scheme during period:

Balance under scheme not yet issued/       640,000
allotted at end of period

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600

Or visit

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