Cheshire, UK--(Marketwire - October 9, 2008) -

Protherics PLC

6 monthly Block Listing Return

Savings Related Share Option Scheme

London, UK; Brentwood, TN; 9 October 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, in accordance with Listing
Rule 3.5.6, notifies the following details in respect of the block
listing for its 1998 Savings Related Share Option Scheme:

Name of applicant:                        Protherics PLC

Name of scheme:                           Protherics PLC Savings
                                          Related Share Option Scheme

Period of return:               From:     9 April    To: 8 October 2008

Balance of unallotted securities under    12,600
scheme at beginning of period:

The amount by which the block scheme has  Nil
been increased during the period:

Number of securities issued/allotted      Nil
under scheme during period:

Balance under scheme not yet issued/      12,600
allotted at end of period

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs +44 (0) 7919 480510  

Julie Vickers, Company Secretary            +44 (0)1928 518010

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott               +44 (0) 20 7831 3113 

New York: John Capodanno                    +1 212 850 5600

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