LONDON and BRENTWOOD, TN--(Marketwire - October 10, 2008) -

Protherics PLC

Rule 2.10 announcement

Not for release, publication or distribution (in whole or in part) in,
into or from any jurisdiction where to do so would constitute a
violation of the relevant laws of such jurisdiction.

London, UK; Brentwood, TN, US: 10 October 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, in accordance with Rule
2.10 of the City Code on Takeovers and Mergers (the "Code"),
confirms that as at the close of business on 9 October 2008, the
Company has   342,560,165 ordinary shares of 2 pence each in issue and
admitted to trading on the London Stock Exchange under the UK ISIN
Code GB0007029209.

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs       +44 (0) 7919 480510

Julie Vickers, Company Secretary                  +44 (0)1928 518010

Jefferies International Limited (Financial        +44 (0) 20 7029 8292

Ian Crosbie, Director

Nomura Code Securities Limited (Corporate Broker) +44 (0) 20 7776 1203

Phil Walker, Director 

Financial Dynamics - press enquiries

London: Ben Atwell, Lara Mott                     +44 (0) 20 7831 3113 

New York: John Capodanno                          +1 212 850 5600

Or visit

Dealing Disclosure Requirements 

Under the provisions of Rule 8.3 of the Code, if any person is, or
becomes "interested" (directly or indirectly) in 1% or more of any
class of "relevant securities" of Protherics, all "dealings" in
any relevant securities" of Protherics (including by means of an option
in respect of, or a derivative references to, any such "relevant
securities") must be publicly disclosed by no later than 3.30pm (London
time) on the London business day following the date of the relevant
transaction. This requirement will continue until the date on which the
offer becomes, or is declared, unconditional as to acceptances, lapses
or is otherwise withdrawn or on which the "offer period" otherwise
ends. If two or more persons act together pursuant to an agreement or
understanding, whether formal or informal, to acquire an "interest" in"relevant securities" of Protherics they will be deemed to a single
person for the purpose of Rule 8.3. 

Under the provisions of Rule 8.1 of the Code, all "dealings" in"relevant securities" of Protherics by the potential offeror, or
by Protherics, or by any of their respective "associates", must be
disclosed by no later than 12.00 noon (London time) on the business day
following the date of the relevant transaction. 

A disclosure table, giving details of the companies in whose "relevant
securities""dealings" should be disclosed, and the number of such
securities in issue, can be found on the Takeover Panel's website at'Interests in securities' arise, in summary, when a person has long
economic exposure, whether conditional or absolute, to changes in the
price of securities. In particular, a person will be treated as having
an 'interest' by virtue of the ownership or control of securities, or
by virtue of any option in respect of, or derivative referenced to,

Terms in quotation marks are defined in the Code, which can also be
found on the Panel's website. If you are in any doubt as to whether or
not you are required to disclose a 'dealing' under Rule 8, you should
consult the Panel.

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