CHESHIRE, UK--(Marketwire - November 20, 2008) -

                            Protherics PLC

               Notification of Major Interests in Shares

London, UK; Brentwood, TN, US: 20 November 2008 - Protherics PLC
("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that, on 19
November 2008, in accordance with the Transparency Obligations
Directive, a notification of interest in the ordinary share capital of
the Company was received from AXA Investment Managers UK Limited on
behalf of AXA S.A. and its Group Companies ("AXA").  Details of the
interest notified are set out below.

1.    Reason for the notification (please tick
the appropriate box or boxes)    

An acquisition of voting rights                  X

An acquisition or disposal of financial
instruments which may result in the acquisition
of shares already issued to which voting rights
are attached

An event changing the breakdown of voting rights

Other (please specify)

2. Full name of person(s) subject to the      AXA S.A., 25 Avenue
notification obligation:                      Matignon, 75008 Paris and
                                              its group of companies.

3. Full name of shareholder(s) (if different
from 2.):

4. Date of the transaction (and date on which 18 November 2008
the threshold is crossed or reached if

5. Date on which issuer notified:             19 November 2008

6. Threshold(s) that is/are crossed or        12%

7. Notified details:

A: Voting rights attached to shares

Class/                Situation previous to 
type of               the Triggering        
shares                transaction 
if                    Number of    Number of  
possible              Shares       Voting Rights      
using the            
ISIN CODE                       

0702920               42,026,712   42,026,712  

Resulting situation after the triggering transaction        

Number of   Number of voting rights    % of voting rights
Direct      Direct     Indirect        Direct   Indirect

1,041,666   1,041,666  41,322,546      0.30%    11.79%

B: Financial Instruments

Resulting situation after the triggering transaction 

Type of     Expiration Exercise/   Number of voting rights that  % of
financial   date       Conversion  may be acquired if the        voting
instrument             Period/     instrument is exercised/      rights
                       Date        converted. 

Total (A+B)

Number of voting rights   % of voting rights
42,364,212                12.09%

8. Chain of controlled undertakings through which the voting rights and
/or the financial instruments are effectively held, if applicable :

Name of Company/Fund                    Number of   % of issued share
                                        Shares      capital

AXA                                     716,666     0.20451   

AXA Framlington                         41,322,546  11.79204

AXA IM UK                               325,000     0.09274

Total Direct                            1,041,666   0.29726
Total Indirect                          41,322,546  11.79204

TOTAL                                   42,364,212  12.08930

Proxy Voting:

9. Name of the proxy holder:

10. Number of voting rights proxy holder will
cease to hold:

11. Date on which proxy holder will cease to hold
voting rights:

12. Additional information:

/ Ends /

For further information please contact:


Nick Staples, Director of Corporate Affairs    +44 (0) 7919 480510  
Julie Vickers, Company Secretary               +44 (0)1928 518010

Financial Dynamics - press enquiries
London: Ben Atwell, Lara Mott                  +44 (0) 20 7831 3113 
New York: John Capodanno                       +1 212 850 5600

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