TopoTarget A/S Symbion Fruebjergvej 3 DK 2100 Copenhagen Denmark Tel: +45 39 17 83 92 Fax: +45 39 17 94 92 CVR-nr: 25695771 www.topotarget.com Copenhagen, Denmark, 26 March 2010 - TopoTarget A/S (NASDAQ OMX: TOPO) has issued 142,750 warrants to its Executive Management. TopoTarget A/S' board of directors has today resolved to issue 142,750 warrants to the company's Chief Executive Officer Francois Martelet. The aim of the issue is to provide an incentive to work towards a positive business performance and, by extension, an increase in the company's value and the market price of the company's shares. Each warrant entitles the holder to subscribe one share of nominal DKK 1 in the company against cash contribution of DKK 5.26. The exercise price corresponds to the average price of the company's shares over the last ten trading days prior to the issue. Using the Black-Scholes model, the market value of the warrant programme can be calculated at DKK 4.14 per warrant. The calculation is based on a volatility of 89,51% and a risk-free interest rate of 3.10%. The warrants vest in blocks of 25%, 25% and 50% on 26th March 2011, 2012 and 2013 respectively. Warrants may be exercised within a period of seven years from the date of grant. When vested, the warrants may be exercised in exercise periods of fourteen days after the first publication of either the company's full-year or half-year reports, and thereafter 14 days after publication of the company´s full-year and half-year reports. The last exercise of the granted warrants has been fixed at fourteen days after the publication of the company's annual report in 2018. This announcement also serves as a company announcement to be made public in accordance with Section 28a of the Danish Securities Trading Act. TopoTarget A/S For further information, please contact: Ulla Hald Buhl Telephone +45 39 17 83 92 Director IR & Communications Mobile +45 21 70 10 49 Background information About TopoTarget TopoTarget (NASDAQ OMX: TOPO) is an international biotech company headquartered in Denmark, dedicated to finding ''Answers for Cancer'' and developing improved cancer therapies. TopoTarget currently focuses, in collaboration with Spectrum Pharmaceuticals, Inc., on the development in pivotal studies of its lead drug candidate, Belinostat, which has shown proof of concept as monotherapy in treating haematological malignancies and positive results in solid tumours. Belinostat can be used in combination with full doses of chemotherapy, and is in a pivotal trial within PTCL (peripheral T-cell lymphoma). TopoTarget's expertise in translational research is based on utilising its highly predictive in vivo and in vitro cancer models. TopoTarget is directing its efforts on key cancer targets, including HDACi, NAD+, mTOR, FASLigand and topoisomerase II inhibitors. The Company's first marketed product, Savene®/Totect®, was approved by EMEA in 2006 and the FDA in 2007, and is marketed by TopoTarget's own sales force in the US. For more information, please refer to www.topotarget.com. TopoTarget Safe Harbour Statement This announcement may contain forward-looking statements, including statements about our expectations of the progression of our preclinical and clinical pipeline including the timing for commencement and completion of clinical trials and with respect to cash burn guidance. Such statements are based on management's current expectations and are subject to a number of risks and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. TopoTarget cautions investors that there can be no assurance that actual results or business conditions will not differ materially from those projected or suggested in such forward-looking statements as a result of various factors, including, but not limited to, the following: The risk that any one or more of the drug development programs of TopoTarget will not proceed as planned for technical, scientific or commercial reasons or due to patient enrolment issues or based on new information from non-clinical or clinical studies or from other sources; the success of competing products and technologies; technological uncertainty and product development risks; uncertainty of additional funding; TopoTarget's history of incurring losses and the uncertainty of achieving profitability; TopoTarget's stage of development as a biopharmaceutical company; government regulation; patent infringement claims against TopoTarget's products, processes and technologies; the ability to protect TopoTarget's patents and proprietary rights; uncertainties relating to commercialization rights; and product liability expo-sure; We disclaim any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, unless required by law.