Pursuant to Article 10 of the Articles of Association, notice is hereby given of the Annual General Meeting to be held on Wednesday, 28 April 2010 at 4.00 p.m. at the Radisson Blu Falconer Hotel & Conference Center, Falkoner Allé 9, DK-2000 Frederiksberg, Copenhagen with the following agenda: 1. The Board of Director's report on the company's activities during the past year 2. Presentation and adoption of the Annual Report 2009 3. The Board of Director's proposed resolution on the distribution of profits and losses as recorded in the Annual Report as adopted 4. Election of Board of Directors Pursuant to Article 17 of the Articles of Association, all Board members elected by the general meeting are up for election. The Board of Directors proposes that all the Board members be re-elected 5. Election of auditor(s) Pursuant to Article 20 of the Articles of Association, the auditor elected by the general meeting is up for election. The Board of Directors proposes that the auditor be re-elected 6. Proposals by the Board of Directors or shareholders: A. The Board of Directors proposes that Article 2 of the Articles of Association regarding the registered address of the company be cancelled B. The Board of Directors proposes that all statements of “aktiebog” (Danish for company's register of shareholders) in the Articles of Association be replaced with “ejerbog” (other Danish word for the company's register of shareholders due to the new Danish Companies Act) C. The Board of Directors proposes that Article 5 of the Articles of Association be replaced by the following new Article 5 authorising the Board of Directors to increase the company's share capital: "Article 5 During the period ending on 28.04.2015, the Board of Directors is authorised to increase the company's share capital in one or more issues of a total nominal sum of up to DKK 97,500,000 (4,875,000 shares of DKK 20 each). The share capital may be increased by cash payment or by other means. If the share capital is increased by cash payment at a subscription price lower than the value of the shares, the existing shareholders are entitled to a right of pre-emption in respect of the amount of the capital increase in proportion to their shareholdings. If the share capital is increased by cash payment otherwise than specified in Article 5(3), above, or is increased by other means, including by debt conversion or in payment of a contribution of assets other than cash, the company's existing shareholders shall not be entitled to any right of pre-emption. If the share capital is increased by other means than cash, the provisions of the Danish Companies Act (selskabsloven) shall apply, and the subscription price or the value of the shares issued shall be fixed by the Board of Directors subject to the mandatory provisions of the Act. All terms and conditions governing the subscription for shares shall be stipulated by the Board of Directors. The new shares shall be negotiable instruments and shall be issued to bearer, but the shares may be registered in the names of the holders in the company's register of shareholders. No restrictions shall apply to the transferability of the new shares, and no shareholder shall be required to have his shares redeemed in whole or in part. The shares shall carry the right to dividend as from the date fixed by the Board of Directors but no later than from the first financial year following the capital increase." D. The Board of Directors proposes that a new Article 5a with the following wording is inserted in the Articles of Association authorising the Board of Directors to issue warrants: "Article 5a During the period ending on 31.12.2011, the Board of Directors is authorised to issue warrants to some or all of the company's and its subsidiaries' employees, members of the Board of Directors and members of the Executive Management in the absolute discretion of and on terms laid down by the Board of Directors entitling the holders to subscribe, in one or more issues, for shares of the total nominal value of DKK 14,000,000 (700,000 shares of DKK 20 each) by cash payment at a price to be determined by the Board of Directors, which price may not be lower than the market price of the company's shares on NASDAQ OMX Copenhagen A/S at the time of the issue of the warrants, and without any right of pre-emption to the company's shareholders. However, the members of the Board of Directors may only be granted warrants to subscribe for shares of up to a nominal value of DKK 1,400,000 (70,000 shares of DKK 20 each). Any new shares subscribed for through exercise of the warrants shall carry the same rights as the existing shares under these Articles, including that the new shares shall be issued to bearer, shall be negotiable instruments, but may be registered in the names of the holders in the company's register of shareholders, that no shareholder shall be required to have his shares redeemed, and that no restrictions shall apply to the transferability of the shares. The new shares shall rank for dividend as from the time of subscription. For the purpose of implementing the capital increase relating to the exercise of the warrants, the Board of Directors is authorised to increase the company's share capital during the period ending on 28.04.2015 in one or more issues by up to the total nominal sum of DKK 14,000,000 (700,000 shares of DKK 20 each) by cash payment at a price to be determined by the Board of Directors, which price may not be lower than the market price of the company's shares on NASDAQ OMX Copenhagen A/S at the time of the issue of the warrants, and without any right of pre-emption to the company's existing shareholders. All other terms and conditions governing the subscription for shares shall be stipulated by the Board of Directors." E. The Board of Directors proposes that Article 5k of the Articles of Association be replaced by the following new Article 5k authorising the Board of Directors to raise loans against issuance of convertible bonds: "Article 5k During the period ending on 28.04.2015, the Board of Directors shall be authorised to resolve on one or more occasions to raise loans of up to DKK 750,000,000, or the equivalent amount in USD or EUR, against issuance of convertible bonds which confer a right to subscribe for shares in the company. Convertible loans may be raised in DKK or the equivalent in USD or EUR computed at the rates of exchange ruling at the day of loan. The Board of Directors may decide to deviate from the shareholders' pre-emption right. If the shareholders' pre-emption right is deviated from, the convertible loans shall be offered at a subscription price and a conversion price that in the aggregate at least corresponds to the market price and conversion price of the shares at the time of the decision of the Board of Directors. The time limit for conversion may be fixed for a longer period than 5 years after the raising of the convertible loan. The loans shall be paid in cash. The specific terms and conditions governing the convertible bonds issued pursuant to the authorisation shall be determined by the Board of Directors. For the purpose of implementing the capital increase relating to the conversion of the convertible debt instruments, the Board of Directors is authorised to increase the company's share capital in one or more issues by a total nominal amount of up to DKK 97,500,000 (4,875,000 shares of DKK 20 each) by conversion of the convertible bonds. The company's existing shareholders shall have no pre-emption rights to shares issued through the conversion of the convertible bonds. The new shares subscribed through conversion shall carry the same rights as the existing shares according to these Articles of Association, including to the effect that the new shares shall be issued to bearer, shall be negotiable instruments, but may be registered in the name of the holder in the company's register of shareholders, that no shareholder shall be obliged to let his shares be redeemed, and that no restrictions shall apply to the transferability of the new shares. The new shares shall rank for dividend from the date of conversion of the convertible bonds into shares, i.e. from the date of subscription." F. The keeper of the company's register of shareholders has changed its name from I-NVESTOR DANMARK A/S to Computershare A/S. Consequently the Board of Directors proposes that Article 8 is amended: “Article 8 The Board of Directors may resolve that the company's register of shareholders be kept either by the company or by an external registrar appointed by the company, on behalf of the company. The company's register of shareholders is kept by Computershare A/S, Kongevejen 418, DK-2840 Holte.” G. As a consequence of the new Danish Companies Act the Board of Directors proposes that Article 11 of the Articles of Association is cancelled and that Articles 10, 12(3), 13 and 15 of the Articles of Association are amended: “Article 10 Within the framework laid down by statute and these Articles of Association, the shareholders in general meeting are the supreme authority in all company matters. General meetings shall be held at the company's registered office or in the Greater Copenhagen Area. General meetings shall be convened by the Board of Directors giving not less than three weeks and not more than five weeks' notice. General meetings shall be advertised on the corporate website (www.neurosearch.com) and in the computer information system of the Danish Commerce and Companies Agency (Erhvervs- og Selskabsstyrelsen). Furthermore, all shareholders registered in the company's register of shareholders, who have so requested, shall be convened by letter. The notice shall set out the agenda of the general meeting and shall specify whether any proposal requiring a special majority of votes is to be considered, including the full wording of such proposal. During the last three weeks before each general meeting the company shall make the following information available on its website: - The notice convening the general meeting - The total number of shares and voting rights at the date of the notice - The documents to be presented at the general meeting - The agenda and the proposed resolutions, set out verbatim, to be considered at the general meeting and, in the case of the Annual General Meeting, also the audited annual report - Forms to be used for voting by proxy or voting by letter" "Article 12(3) Any proposals from the shareholders to be considered at the Annual General Meeting must be submitted to the company not later than six weeks before the general meeting.” "Article 13 Extraordinary general meetings shall be held whenever a general meeting, the Board of Directors or the auditor thinks fit or upon a written request to the Board of Directors from any shareholder who holds not less than 5% of the company's share capital. Shareholder requests shall specify the nature of the business to be considered at the general meeting. The general meeting shall be convened within 2 weeks of receipt of the request by the Board of Directors." "THE RIGHT TO ATTEND AND VOTING RIGTHS Article 15 Any shareholder is entitled to attend the general meeting and vote on the shares held by the shareholder at the record date when the ownership of these shares is notified to the keeper of the company's register of shareholders no later than the record date. The record date is one week before the general meeting. In order to attend the general meeting the shareholder must request an admission card from the company no later than three days prior to the general meeting. The shareholder may attend in person or by proxy. In both cases a counsellor is permitted. Each share of DKK 1 shall carry one vote at the general meetings. Voting rights may be exercised by written proxy or by voting by letter and the company must make such forms available on the company website (www.neurosearch.com) no later than 3 weeks prior to the general meeting." H. The Board of Directors proposes that Articles 14(4) and 18a of the Articles of Association are aligned with the new Danish Companies Act and amended: “Article 14(4) Not later than 2 weeks after a general meeting, the minutes of the general meeting or a certified copy thereof shall be available for inspection by the shareholders at the company's office.” “Article 18a Guidelines for incentive payment to the members of the Board of Directors and the Executive Management have been adopted. The guidelines are available on the corporate website (www.neurosearch.com).” The Board of Directors further proposes that the following sentence be included at the end of Article 15(4) of the Articles of Association: “A vote by letter must be received by the company no later than 3 days prior to the general meeting in order to be considered at the general meeting.” I. The Board of Directors proposes that the requirement concerning quorum is removed and that Article 16(2) of the Articles of Association is amended: “Article 16(2) Unless Danish legislation provides for a greater majority or unanimity, the adoption of any resolution to amend these Articles of Association, to dissolve or merge the company shall require a majority of votes of at least two-thirds of the votes cast as well as of the voting share capital represented at the general meeting.” J. The Board of Directors proposes that Board of Directors is authorised to re-number the articles in the Articles of Association. K. The Board of Directors presents new guidelines for incentive payments to the Board of Directors and the Management for approval by the general meeting. Pursuant to Article 139 of the Danish Companies Act, a listed company shall have general guidelines for incentive payments to the Board of Directors and the Executive Management if the company uses incentive payments as part of the remuneration of its Board of Directors or the Management. The new guidelines must be considered and approved by the general meeting and are enclosed to this notice. 7. The Board of Directors requests the general meeting to authorise the company during the period until the next Annual General Meeting to purchase its own shares of up to a total nominal value of 10% of the company's share capital. The payment must not differ by more than 10% from the bid price quoted on NASDAQ OMX Copenhagen A/S at the time of the purchase. 8. Any other business The resolution under item 6.G, shall be subject to the proposed resolution being adopted by no less than one (1) vote cast, cf. promulgation of partial entry into force of the Danish act on Danish Private Companies (The Danish Companies Act) Article 55(2) and (3). Any resolution under items 6.A, 6.B, 6.C, 6.D, 6.E, 6.F, 6.H, 6.I and 6.J above, see Article 16 of the Articles of Association, shall be subject to the proposed resolution being adopted by no less than two-thirds of all votes cast and of the voting share capital represented at the Annual General Meeting, and no less than one half of the share capital being represented at the meeting. If one half of the share capital is not represented at the meeting, but the proposed resolution is passed by no less than two-thirds of the votes cast and of the voting share capital represented at the meeting, a new general meeting will be held within 14 days to pass the resolution by no less than two-thirds of both the votes cast and of the voting share capital represented at the meeting. The share capital of NeuroSearch A/S is nominally DKK 491,078,940 (24,553,947 shares of DKK 20 each). Each share of DKK 1 carries one vote. Pursuant to Article 11 of the Articles of Association, all shareholders who wish to attend the Annual General Meeting must order admission cards via the company's website, www.neurosearch.com, from NeuroSearch A/S, Pederstrupvej 93, DK-2750 Ballerup (telephone: +45 4460 8000, ns@neurosearch.dk) or from Computershare A/S, Kongevejen 418, DK-2840 Holte (telefax: +45 4546 0998) no later than Friday 23 April 2010. All shareholders not registered in the company's register of shareholders who wish to attend the Annual General Meeting must establish good title to their shares by presentation of documentation from their financial institute, such documentation not to have been issued more than 14 days before the Annual General Meeting. The shareholders must also issue a statement in writing to the effect that their shares have not been and will not be transferred to any third party before the Annual General Meeting. Shareholders who are unable to attend the Annual General Meeting may issue a proxy to the Board of Directors or to a third party directly via www.neurosearch.com. The proxy form may also be printed from the website or be requested from NeuroSearch A/S. Signed and dated proxies must be received by Computershare A/S no later than Friday, 23 April 2010. The company will publish the documents to be presented at the general meeting including the audited Annual Report 2009 and agenda of the meeting and the complete proposals on the corporate website no later than Wednesday, 7 April 2010 Please note that an Extraordinary General Meeting to be held on 3 May 2010 in accordance with Articles 10 and 16 of the Articles of Association is convened in a separate notice. The notice to convene the Extraordinary General Meeting is sent together with the notice convening the Annual General Meeting. Thomas Hofman-Bang Chairman of the Board of Directors Contact persons: Flemming Pedersen, CEO, tel: +45 4460 8214 or +45 2148 0118 Hanne Leth Hillman, Vice President, Director of Investor & Capital Market Relations, tel: +45 4460 8212 or +45 4017 5103 About NeuroSearch - Company profile NeuroSearch (NEUR) is a Scandinavian biopharmaceutical company listed on NASDAQ OMX Copenhagen A/S. The core business of the company covers the development of novel pharmaceutical agents, based on a broad and well-established drug discovery platform, focusing on ion channels and central nervous system (CNS) disorders. A substantial share of the activities is partner financed through strategic alliances with Janssen Pharmaceutica, Eli Lilly and Company and GlaxoSmithKline, and licence collaboration with Abbott. The drug pipeline comprises eight clinical (Phase I-III) development programmes: Huntexil® (pridopidine) for Huntington's disease (Phase III), tesofensine for obesity (ready for Phase III), ABT-894 for ADHD (Phase II) in partnership with Abbott, ACR343 for schizophrenia (ready for Phase II), ACR325 to treat dyskinesias in Parkinson's disease (Phase Ib), ABT-560 for the treatment of cognitive dysfunctions (Phase I) in collaboration with Abbott, NSD-788 for anxiety/depression (Phase I) and NSD-721 for social anxiety disorder (Phase I) in partnership with GSK. In addition, NeuroSearch has a broad portfolio of preclinical drug candidates and holds equity interests in several biotech companies. ------------------------- General guidelines pursuant to Article 139 of the Danish Companies Act governing incentive plans for the Board of Directors and Executive Management Introduction Pursuant to Article 139 of the Danish Companies Act, the Board of Directors of a listed company is required to define general guidelines for the company's incentive pay for the Board of Directors and Executive Management before entering into a specific agreement on incentive pay with any member of the company's Board of Directors or Executive Management. The guidelines must be considered and adopted by the company's shareholders. These guidelines consequently include the general guidelines on incentive plans for the Board of Directors and Executive Management of NeuroSearch A/S. General principles To create coincidence of interests between the Board of Directors and Executive Management of NeuroSearch A/S and the company's shareholders and to consider both short-term and long-term targets, NeuroSearch A/S considers it expedient to set up incentive plans for the members of its Executive Management. Such incentive plans may consist of warrants and non-share-based bonus agreements, which may be continuous, one-off and event-based. NeuroSearch A/S also considers it appropriate to remunerate the members of the company's Board of Directors with warrants. If NeuroSearch A/S wants to enter into specific agreements on incentive plans with members of the Board of Directors and Executive Management, such specific agreements must be subject to these guidelines. These guidelines solely comprise incentive plans for the members of the Board of Directors and the registered Executive Management of NeuroSearch A/S. Share-based instruments The exercise price of the warrants granted will be determined on the basis of an average of the market price five days before and five days after the date of grant, provided always that the exercise price must, as a minimum, correspond to the company's average market price on the day of the formal resolution to grant warrants. It may be decided that the warrants granted vest on an ongoing basis during a period of one to three years from the date of grant. Warrants cannot be exercised until three years from the date of grant and must be exercised not later than five years from the date of grant. For the members of both the Board of Directors and the Executive Management, the value of the warrants granted within a given calendar year may amount to up to 100% of their fixed base salary/fees. The value of the warrants granted will be determined in accordance with the Black & Scholes formula. No consideration will be payable for the warrants. In respect of each grant, the Board of Directors will assess whether the recommended number of warrants to each recipient is commensurate with the recipient's participation in the achievement of the long-term targets and strategies of the company. The warrants to the Executive Management will vest gradually, subject to continuing employment of the members of the Executive Management. Non-share-based instruments The Board of Directors may enter into agreements with the Executive Management about cash bonus plans. Cash bonus plans consist of a maximum bonus fixed annually which the Executive Management will receive if all targets for the relevant year are met. The maximum cash bonus shall be equivalent to 100% of the base salary of each member of the Executive Management. Payment of bonus depends on whether the conditions and targets defined in the agreement have been fully or partly met. This may be personal targets related to the performance of the individual member of the Executive Management or the performance of NeuroSearch A/S. In exceptional cases, other agreements that may lead to payment of a bonus of up to one year's base salary may be made. Such agreements are typically expected to be made so as to take effect upon the occurrence of a specific event, for instance the acquisition of a controlling interest in the company, the completion of a takeover bid, the continuing employment of the Executive Management until a specific point in time, defined either as a date or a period after the occurrence of a specific event. Change and phase-out of incentive plan The Board of Directors may change or phase out one or more incentive plans introduced pursuant to these guidelines. In the evaluation of whether this should be done, the criteria that formed the basis of the establishment of the plan will be taken into account. However, such changes can only be made within the framework of these guidelines. More extensive changes must be approved by the shareholders. Publication There is a provision in the company's Articles of Association stating that the shareholders have adopted guidelines for incentive pay for members of the Board of Directors and Executive Management pursuant to Article 139 of the Danish Companies Act. These guidelines will also be published on the company's webpage.
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