FOURTH QUARTER AND FULL YEAR RESULTS 2011


FOURTH QUARTER AND FULL YEAR RESULTS 2011

London, 2 February 2012

Revenue for the full year was down 2 percent at constant exchange rates (CER) at
$33,591 million.

-Strong double-digit sales growth at CER for Crestor, Seroquel XR and Symbicort;
Emerging Markets revenue increased by 10 percent at CER in the fourth quarter
and for the full year.

-Revenue performance reflects the loss of nearly $2 billion of revenue from
generic competition, as well as a further $1 billion lost to the impact of
government price interventions.

Core operating profit for the full year was down 4 percent at CER to $13,167
million.

-Core operating margin of 39.2 percent of revenue was down 1.2 percentage points
at CER, as benefits arising from higher gross margin and lower SG&A spend at CER
were more than offset by increased expenditures in R&D and lower Core other
income.

Core EPS for the full year increased by 7 percent at CER to $7.28.

-Core EPS benefited from the lower number of shares outstanding resulting from
net share repurchases and a lower tax rate compared with last year.

Reported EPS for the full year was up 29 percent at CER to $7.33.

-Gain on the sale of Astra Tech, which was excluded from Core EPS in the third
quarter 2011, amounted to $1.08. The growth rate in Reported EPS also benefited
from the fact that intangible impairments excluded from Core earnings were
higher in 2010.   

Revenue in the fourth quarter unchanged at CER; Core EPS was up 12 percent at
CER.

Net cash distributions to shareholders increased by 71 percent to $9,370
million.

-Dividend increased by 10 percent to $2.80 for the full year. Net share
repurchases total $5.6 billion in 2011.

-Board announces plans for $4.5 billion in net share repurchases for 2012.

Company reaffirms planning assumptions for total revenue, margins and cash
deployment for the period 2010-14.

-Risk adjusted revenue from recently launched and pipeline products lowered to
range of $2 to $4 billion.

Company announces new set of restructuring initiatives (see page 3).  

Financial Summary

+----------+-----------+-----------+------+---+---------+---------+------+---+
|Group     |4th Quarter|4th Quarter|Actual|CER|Full Year|Full Year|Actual|CER|
|          |       2011|       2010|     %|  %|     2011|     2010|     %|  %|
|          |         $m|         $m|      |   |       $m|       $m|      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|   Revenue|      8,656|      8,617|     -|  -|   33,591|   33,269|    +1| -2|
+----------+-----------+-----------+------+---+---------+---------+------+---+
|Reported  |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|          |      2,167|      2,411|   -10|-14|   12,795|   11,494|   +11|+10|
|Operating |           |           |      |   |         |         |      |   |
|Profit    |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|   Profit |      2,052|      2,283|   -10|-14|   12,367|   10,977|   +13|+11|
|before Tax|           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|          |      $1.16|      $1.15|     -| -5|    $7.33|    $5.60|   +31|+29|
|Earnings  |           |           |      |   |         |         |      |   |
|per Share |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|Core*     |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|          |      2,990|      2,865|    +4| +1|   13,167|   13,603|    -3| -4|
|Operating |           |           |      |   |         |         |      |   |
|Profit    |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|   Profit |      2,875|      2,737|    +5| +1|   12,739|   13,086|    -3| -4|
|before Tax|           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+
|          |      $1.61|      $1.39|   +16|+12|    $7.28|    $6.71|    +9| +7|
|Earnings  |           |           |      |   |         |         |      |   |
|per Share |           |           |      |   |         |         |      |   |
+----------+-----------+-----------+------+---+---------+---------+------+---+

* Core financial measures are supplemental non-GAAP measures which management
believe enhance understanding of the Company’s performance; it is upon these
measures that financial guidance for 2012 is based. See page 13 for a definition
of Core financial measures and pages 13 and 14 for a reconciliation of Core to
Reported financial measures.

David Brennan, Chief Executive Officer, said: “Disciplined execution of our
strategy has delivered a good performance in 2011 in the face of intensified
pricing pressure and generic competition. Our strong cash flow supported a
significant increase in cash distributions to shareholders and continued
investment to drive future growth and value. While the further expected losses
of market exclusivity make for a challenging 2012 outlook, we remain committed
to a long-term, focused, R&D based strategy, and today we have announced further
steps to drive productivity in all areas to improve returns on our investment in
innovation.”
 

Media           Esra Erkal-Paler (London)       +44 20 7604 8030
Enquiries:
                Abigail Baron (London)          +44 20 7604 8034
                Tony Jewell (Wilmington)        +1 302 885 4594
                Ann-Leena Mikiver (Södertälje)  +46 8 553 260 20/+46 707 428836

Analyst/Invest  James Ward-Lilley (London)      +44 20 7604 8122
or Enquiries:
                Karl Hård (London)              +44 20 7604 8123
                Nicklas Westerholm (London)     +44 20 7604 8124
                Ed Seage/Jörgen Winroth (US)    +1 302 886 4065/+1 212 579 0506

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