Company’s Monoclonal Antibody, OSE-703, to be Significant Focus of Research
NANTES, France, Dec. 14, 2017 (GLOBE NEWSWIRE) -- OSE Immunotherapeutics (ISIN: FR0012127173) (Mnémo:OSE), today announces that the Company will receive a €398,000 grant from the “Fonds Unique Interministériel” (FUI), dedicated to the financing of competitiveness cluster projects, to identify new monoclonal antibodies and therapeutic targets. This collaborative program is focused on developing innovative tests to explore and to measure the cytotoxicity of monoclonal antibodies. Out of a total project cost of €2.4 million, the FUI is providing €1.2 million to fund this research that will be conducted by OSE Immunotherapeutics, Clean Cells (leader of the consortium), INSERM (UMR1232-CNRS ERL6001, Nantes), and the MicroPICell Federative Research Structure François Bonamy (Nantes).
The collaborative research project, entitled HybridADCC, will identify novel monoclonal antibodies and develop an innovative and standardized test that measures the ability of therapeutic antibodies to destroy tumour cells (or infected cells) through a mechanism of toxicity called Antibody-Dependent Cell-mediated Cytotoxicity (ADCC).
Through this research project, OSE Immunotherapeutics will have access to a platform to identify, to develop and to validate cytotoxic antibodies targeting new product candidates in immuno-oncology. One of the product candidates to be evaluated is OSE Immunotherapeutics’ cytotoxic antibody, OSE-703, currently being explored in lung cancer by Dr. Prasad Adusumilli’s team at Memorial Sloan Kettering Cancer Center in New York. The HybridADCC program also will evaluate the in vitro efficacy of OSE-703 in other cancers of interest.
Bernard Vanhove, COO of OSE Immunotherapeutics, Head of R&D and International Scientific Collaborations, commented: “As a result of this innovative program, OSE could gain new monoclonal antibodies on targets of therapeutic interest, and generate additional product candidates for clinical development in immuno-oncology, used in monotherapy or combined with a checkpoint inhibitor.”
ABOUT OSE Immunotherapeutics
Our ambition is to become a world leader in activation and regulation immunotherapies:
OSE Immunotherapeutics is a biotechnology company focused on the development of innovative immunotherapies for immune activation and regulation in the fields of immuno-oncology, autoimmune diseases and transplantation. The company has several scientific and technological platforms: neoepitopes, agonist or antagonist monoclonal antibodies, ideally positioned to fight cancer and autoimmune diseases. Its first-in-class clinical portfolio offers a diversified risk profile.
In auto-immune diseases and transplantation:
The portfolio’s blockbuster potential gives OSE Immunotherapeutics the ability to enter global agreements at different stages of development with major pharmaceutical players.
Immunotherapy is a highly promising and growing market. By 2023 Immunotherapy of cancer could represent nearly 60% of treatments against less than 3% at present * and the projected market is estimated at $67 billion in 2018 **. There are more than 80 autoimmune diseases that represent a significant market including major players in the pharmaceutical industry with sales towards $10 billion for the main products. The medical need is largely unmet and requires the provision of new innovative products involved in the regulation of the immune system.
*Citi Research Equity
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This press release includes only summary information and should be read with the OSE Immunotherapeutics Reference Document filed with the AMF on 28 April 2017 under the number R.17-038, including the annual financial report for the fiscal year 2016, available on the OSE Immunotherapeutics’ website.
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