Dublin, Nov. 30, 2018 (GLOBE NEWSWIRE) -- The "Chromatography in Pharmaceuticals and Biotechnology: Global Markets" report has been added to ResearchAndMarkets.com's offering.
Chromatography accounted for nearly 21% of the overall market in 2015. Chromatography is a valuable tool particularly in the pharmaceutical and biotechnology sectors as it can provide highly sensitive information about product quality and purity. The implementation of process analytical technology has also given a boost to this market. The growing demands of biopharmaceuticals, particularly monoclonal antibodies, biosimilar drugs and others have also necessitated biotechnology and biopharmaceutical industries to invest in high-throughput bioprocessing and downstream processing instruments. The advances in technology for the development of improved systems, innovative and disposable columns, better-performing resins, and other accessories are helping this market to grow significantly.
This report provides a comprehensive analysis of the chromatography market in the global context, including market forecasts and sales through 2023. The report includes assessment of the chromatography market by segmenting it into the broad categories of instruments and reagents followed by thorough analyses of various techniques of chromatography for each category. These include liquid chromatography (ion-exchange, hydrophobic-interaction, size-exclusion, flash), high-pressure liquid chromatography (HPLC)/ultra-high-pressure liquid chromatography (UHPLC), thin layer chromatography, gas chromatography, supercritical fluid chromatography and affinity chromatography.
Chromatography occupies a prominent place in the analytical and separation domain, particularly in the pharmaceutical and biotechnology sectors. The technique has evolved from a simple paper chromatography method to a high-pressure, high-performance method that has the capacity to detect in the range of nanomolar and picomolar concentrations in substances. The advances in technology have brought about improvements in chromatography methods leading to higher resolutions, peak separation, enhanced sensitivity, and faster speeds of analysis. The growing need for data integrity and automation has led to the integration of sophisticated software with contemporary chromatography
systems.
There are a growing number of diseases and aging populations around the world. The need for innovative therapies and drugs has intensified drug research activities. Proteomics and metabolomics studies have also been directed at the characterization of new biomarkers and unidentified proteins that will lead to better diagnoses. An increase in the demand for chromatography instruments and reagents for research and development is a major factor driving the growth of the global chromatography market. The addition of high-throughput capabilities to the modern chromatography systems in addition to improved resolutions and sensitivities by combining the use of chromatography with mass spectrometry-based methods have greatly increased the scope of use in clinical diagnostics. The growing stringency of U.S. FDA (Food and Drug Administration) regulations to meet the CGMP (current good manufacturing practices) guidelines in drug manufacturing processes, as well as final drug quality, has increased the demand for chromatography in drug quality control. Downstream processing of biologics drugs has witnessed an increased activity since biosimilar drugs and other innovative biologics (monoclonal antibodies) have gained popularity.
The traditional chromatography techniques suffered from limitations of poor resolution, slow analysis, and low detection limits. Enhancements in technologies for detection, multiple sample injection, fraction collection and inert and pressure-resistant accessories, coupled with innovation in column technologies and novel stationary phases, have resulted in new chromatography modes and systems. These include ultra-high-performance liquid chromatography (UHPLC) and supercritical fluid chromatography (SFC). High-performance TLC and affinity chromatography have also gained prominence as superior analytical methods. Another domain of chromatography that is rapidly developing is the multi-dimensional chromatography (MDC) that can achieve far higher resolutions than possible with the usual one-dimensional methods. Designs of miniaturized systems and chip-based chromatography systems with micro-and nano-flow technology are the latest additions driving the growth of the chromatography market.
Merger and acquisition activities are also driving the chromatography market in the pharmaceutical/biotechnology sectors, increased budgets for research (from both government andindustries), and growing healthcare infrastructure particularly in the emerging countries.
The restraints that hinder the growth of the global chromatography market are the high cost of chromatography equipment and expensive resins and packing material. Moreover, the need for skilled personnel also limits the use of chromatography techniques in routine applications. The ever-increasing complexity of drug compounds and biomolecules has necessitated innovation in chromatography resin chemistries and functional groups to meet these demands.
Key Topics Covered:
Chapter 1 Introduction
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
- Principles of Chromatography
- Mobile Phase
- A Typical Chromatography Process
- History of Chromatography
- Downstream Processing
- Analytical Characterization of Proteins
- Drug Discovery and Development
- Clinical Analysis/Diagnostics
- Chromatography Instruments
- Chromatography Systems/Chromatographs
- Columns and Column Accessories
- Detectors
- Fraction Collectors
- Injectors and Autosamplers
- Pumps
- Accessories
- Chromatography Reagents
- Packing Material (Resin)
- Solvents
- Buffers
- Derivatives
- Modifiers
- Chromatography Standards
- Chromatography Software
- Classification of Chromatography
- Based on Scale of Chromatography
- Based on Type of Stationary Phase
- Based on Type of Mobile Phase
- Types of Chromatography
- Liquid Chromatography
- High-Performance Liquid Chromatography (HPLC)/Ultra High-Performance Liquid Chromatography (UHPLC)
- Thin Layer Chromatography (TLC)
- Gas Chromatography (GC)
- Supercritical Fluid Chromatography (SFC)
- Affinity Chromatography
Chapter 4 Market Breakdown by Technology Type
- Market by Chromatography Product Types
- Market Analysis of Chromatography Instruments Segment
- Market by Chromatography Technology Types
- Market Analysis of Chromatography Reagents Segment
Chapter 5 Market Breakdown by Application
- Market by Application
- Market Revenue
- Market Shares
- Drug Discovery and Development
- Downstream Processing
- Proteomics
- Diagnostics
- Pharmaceutical Analysis
- Metabolomics
Chapter 6 Market Breakdown by Region
- Market by Geographical Region
- Market Revenue
- Market Shares
- Gas Chromatography
- Thin Layer Chromatography
- Supercritical Fluid Chromatography
- Liquid Chromatography
- High-Performance Liquid Chromatography/Ultra High-Performance Liquid Chromatography (HPLC/UHPLC)
- Affinity Chromatography
Chapter 7 Industry Structure
- Regulatory and Compliance
- Overview
- Industry Structure
- Industry Trends in Chromatography Market
- Consumable Bundle Offerings
- Mergers and Acquisitions
- Collaborations and Partnerships
- Buying and Selling Chromatography Products
- Leading Manufacturers/Suppliers of Chromatography Instruments and Reagents
- Gas Chromatography (GC)
- Supercritical Fluid Chromatography (SFC)
- Thin Layer Chromatography (TLC)
- Liquid Chromatography (LC)
- High-Performance Liquid Chromatography (HPLC)/Ultra-Performance Liquid Chromatography (UPLC)
- Affinity Chromatography
Chapter 8 Patent Review
- Patents in Chromatography Market
- Patent Analysis
- Patents by Year
- Patents by Category
- Patents by Type
- Patents by Company
- Patents by Country
- Patents by Assignee
Chapter 9 New Developments/Regulatory Aspects
- New Developments
- New Developments in Chromatography Instruments
- New Developments in Chromatography Reagents
- Regulatory Aspects
- Guidelines Related to Analytical Method Validation -- General Concepts
- Guidelines Related to Downstream Processing -- General Concepts
- Guidelines Related to Chromatography Data Integrity
Chapter 10 Technology Trends
- Emerging Trends in Chromatography Instruments
- Miniaturization of Chromatography Columns and Systems
- Disposable/Pre-packed Columns
- Membrane Technology
- Rapid and High-Throughput Separations
- Microfluidic Chromatography
- Multi-Dimensional Chromatography
- Continuous Chromatography
- Novel Detectors
- Trends in Chromatography Data Systems (CDSs)
- Emerging Trends in Chromatography Reagents
- Novel Chromatography Resins
- Affinity Resins
- Improved Buffers
- High-Purity Solvents
- Emerging Trends in Chromatography Applications
- Application of GC-VUV in Residual Solvent Characterization
- Integration of Chromatography for High-Throughput Drug Discovery and Chemical Syntheses Studies
- Application of UHPLC-MS/MS for Identifying DNA/RNA Modifications
- Multi-Dimensional Chromatography is a Promising Method for Identification of the Nucleoside Modifications
- Application of 2D-LC in Quality Control
- Application of 2D-LC in Characterization of Antibody-Drug Conjugates (ADCs)
- Developments in the Purification of Bi-specific Antibodies
Chapter 11 Analysis of Market Opportunities
- Strengths of Chromatography Market
- Rising Incidence of Diseases
- Growing Demand for Biopharmaceuticals
- New Product Launches
- Increased Government Spending
- Contract Manufacturing Organizations (CMOs) and Contract Research Organizations (CROs)
- Mergers and Acquisitions
- Challenges of Chromatography Market
- Lack of Skilled Labor
- Cost of Equipment
- Protein A Resins
- Scale-up of Chromatography Processes
- Continuous Chromatography
- Opportunities for Chromatography Market
- Emerging Markets
- Technological Advances
- Process Analytical Technology (PAT) Initiative
- Novel Protein A Resins
- Multi-Dimensional Chromatography and Process Intensification
- Threats for Chromatography Market
- Government Regulations
- Competition
Chapter 12 Company Profiles
- AB Sciex LLC
- Abbkine Scientific Co. Ltd.
- Ads Biotec Inc.
- Advanced Materials Technology Inc.
- Advent Chembio Pvt. Ltd.
- Advion Inc.
- Agilent Technologies, Inc.
- Anawa Trading AG
- Antec Scientific
- Asynt Ltd.
- Bio-Lab Ltd.
- Bio-Rad Laboratories Inc.
- Biotage AB
- Biotoolomics Ltd.
- Bischoff Chromatography
- Bruker Corp.
- Camag Chemie-Erzeugnisse & Adsorptionstechnik Ag
- Cecil Instruments Ltd.
- Chiral Technologies Inc.
- Daiso Fine Chem Usa Inc.
- Danaher Corp.
- Es Industries, Inc.
- Finar Ltd.
- Ge Healthcare Life Sciences
- Gilson Inc.
- Gl Sciences Inc.
- Hamilton Co.
- Hichrom Ltd.
- Hitachi High-Technologies Corp.
- Imtakt USA
- Jasco Inc.
- Jsr Life Sciences
- Knauer Wissenschaftliche Gerate Gmbh
- Labomatic Instruments AG
- Macherey-Nagel Gmbh & Co.
- Microsolv Technology Corp.
- Milliporesigma
- Novasep Inc.
- Perkinelmer, Inc.
- Phenomenex Inc.
- Purolite Corp.
- Qiagen, N.V.
- Quadrex Corp.
- Regis Technologies Inc.
- Repligen Corp.
- Restek Corp.
- Rotachrom Technologies Ltd.
- Sartorius Stedim Biotech GmbH
- Scion Instruments
- Sepragen Corp.
- Shimadzu Corp.
- Showa Denko K.K.
- Sino Biological Inc.
- Sorbent Technologies, Inc.
- Sterogene Bioseparations Inc.
- Teledyne Isco
- Teledyne Tekmar
- Thermo Fisher Scientific Inc.
- Tosoh Bioscience LLC
- Vuv Analytics Inc.
- W. L. Gore & Associates Inc.
- Waters Corp.
- YMC America Inc.
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